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Tbio
CCDC120
Coiled-coil domain-containing protein 120

Protein Summary
Description
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. This gene encodes a protein that contains a coiled-coil domain. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000496529
  • ENSP00000474761
  • ENSG00000147144
  • ENST00000536628
  • ENSP00000443351
  • ENST00000597275
  • ENSP00000470294
  • ENST00000603986
  • ENSP00000474071
  • ENST00000606812
  • ENSP00000475676

Symbol
  • JM11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.67
cell line
0.61
cell type or tissue
0.58
kinase perturbation
0.54
transcription factor
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (72)
1 – 10 of 72
CYTH4
Tbio
Novelty: 0.05783135
p_int: 0.999999993
p_ni: 5e-9
p_wrong: 2e-9
Score: 0.171
Data Source: BioPlex,STRINGDB
SDCCAG8
Tbio
Novelty: 0.0431837
p_int: 0.999999919
p_ni: 7.9e-8
p_wrong: 1e-9
Data Source: BioPlex
CYTH1
Tbio
Novelty: 0.00635156
p_int: 0.999999678
p_ni: 3.22e-7
Score: 0.225
Data Source: BioPlex,STRINGDB
CYTH2
Tbio
Novelty: 0.03560664
p_int: 0.999999092
p_ni: 9.08e-7
Score: 0.752
Data Source: BioPlex,STRINGDB
MEIS2
Tbio
Family: TF
Novelty: 0.01393828
p_int: 0.999992351
p_ni: 0.000007626
p_wrong: 2.3e-8
Score: 0.546
Data Source: BioPlex,STRINGDB
MORN2
Tdark
Novelty: 0.07736482
p_int: 0.999982971
p_ni: 4e-9
p_wrong: 0.000017026
Score: 0.189
Data Source: BioPlex,STRINGDB
CYTH3
Tbio
Novelty: 0.00940752
p_int: 0.999972135
p_ni: 0.000027865
Score: 0.275
Data Source: BioPlex,STRINGDB
INA
Tbio
Novelty: 0.00708581
p_int: 0.999968325
p_ni: 0.000031675
Data Source: BioPlex
PBX2
Tbio
Family: TF
Novelty: 0.01339291
p_int: 0.999838994
p_ni: 0.000161006
Data Source: BioPlex
PKNOX1
Tbio
Family: TF
Novelty: 0.01063674
p_int: 0.999826113
p_ni: 0.00003277
p_wrong: 0.000141117
Score: 0.517
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.24

PubMed score by year
PubTator Score  0.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer