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Tbio
OAZ1
Ornithine decarboxylase antizyme 1

Protein Classes
Protein Summary
Description
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147). The protein encoded by this gene belongs to the ornithine decarboxylase antizym ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000602676
  • ENSP00000473381
  • ENSG00000104904

Symbol
  • OAZ
  • AZ1
  • AZI
  • OAZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
virus perturbation
0.88
transcription factor perturbation
0.84
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.33   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.33   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Reactome
Regulation of ornithine decarboxylase (ODC)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Regulation of ornithine decarboxylase (ODC)
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (128)
1 – 10 of 128
AZIN2
Tbio
Family: Enzyme
Novelty: 0.00750311
p_int: 1
Score: 0.87
Data Source: BioPlex,STRINGDB
AZIN1
Tbio
Family: Enzyme
Novelty: 0.03017595
p_int: 0.999999026
p_ni: 9.4e-7
p_wrong: 3.4e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ODC1
Tclin
Family: Enzyme
Novelty: 0.00037968
Score: 0.999
Data Source: Reactome,STRINGDB
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
Score: 0.965
Data Source: STRINGDB
AURKAIP1
Tchem
Family: Enzyme
Novelty: 0.19241693
Score: 0.955
Data Source: STRINGDB
PSMA3
Tbio
Family: Enzyme
Novelty: 0.03106507
Score: 0.955
Data Source: STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
Score: 0.953
Data Source: STRINGDB
OAZ3
Tbio
Family: Enzyme
Novelty: 0.02374168
Score: 0.945
Data Source: STRINGDB
OAZ2
Tbio
Family: Enzyme
Novelty: 0.1687351
Score: 0.94
Data Source: STRINGDB
PSMB6
Tbio
Family: Enzyme
Novelty: 0.04738037
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.33

PubMed score by year
PubTator Score  42.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer