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Tbio
RUVBL2
RuvB-like 2

Protein Summary
Description
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000595090
  • ENSP00000473172
  • ENSG00000183207

Symbol
  • INO80J
  • TIP48
  • TIP49B
  • RVB2
  • TIH2
  • ECP51
  • TIP48
  • CGI-46
  • ECP-51
  • INO80J
  • REPTIN
  • TIP49B
  • TAP54-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein complex
0.99
biological process
0.97
co-expressed gene
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.71   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.71   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
3
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
95.9
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Chromosome Maintenance
Reactome
Extension of Telomeres
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromatin modifying enzymes
Chromatin organization
Chromosome Maintenance
Extension of Telomeres
Gene Ontology Terms (50)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (407)
1 – 10 of 407
DPCD
Tbio
Novelty: 0.09869683
p_int: 0.999999996
p_ni: 2e-9
p_wrong: 2e-9
Score: 0.854
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR8
Tbio
Novelty: 0.12366847
p_int: 0.999999962
p_ni: 3.8e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
INO80D
Tdark
Novelty: 0.33070971
p_int: 0.999999922
p_ni: 3.7e-8
p_wrong: 4.1e-8
Score: 0.792
Data Source: BioPlex,STRINGDB
ACTR5
Tbio
Novelty: 0.15502033
p_int: 0.999999899
p_ni: 1e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
INO80B
Tbio
Novelty: 0.02405051
p_int: 0.999999509
p_ni: 4.59e-7
p_wrong: 3.2e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
NFRKB
Tbio
Novelty: 0.13445983
p_int: 0.99999939
p_ni: 6.1e-7
Score: 0.929
Data Source: BioPlex,STRINGDB
WDCP
Tdark
Novelty: 0.29184907
p_int: 0.999996505
p_ni: 0.000003495
Score: 0.313
Data Source: BioPlex,STRINGDB
EPC2
Tbio
Novelty: 0.02760809
p_int: 0.999995435
p_ni: 0.000004565
Score: 0.906
Data Source: BioPlex,STRINGDB
EPC1
Tbio
Novelty: 0.03216371
p_int: 0.999994611
p_ni: 0.000005389
Score: 0.976
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  97.71

PubMed score by year
PubTator Score  85.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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