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Tbio
HAMP
Hepcidin

Protein Summary
Description
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317). The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222304
  • ENSP00000222304
  • ENSG00000105697
  • ENST00000598398
  • ENSP00000471894

Symbol
  • HEPC
  • LEAP1
  • HEPC
  • PLTR
  • HFE2B
  • LEAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
small molecule perturbation
0.6
cell type or tissue
0.58
disease
0.58
co-expressed gene
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3334.95   (req: < 5)
Gene RIFs: 383   (req: <= 3)
Antibodies: 404   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3334.95   (req: >= 5)
Gene RIFs: 383   (req: > 3)
Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
3
62.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
62.3
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (102)
1 – 10 of 102
HJV
Tbio
Novelty: 0.00495995
Score: 0.969
Data Source: STRINGDB
TFR2
Tbio
Family: Enzyme
Novelty: 0.00480264
Score: 0.968
Data Source: STRINGDB
HFE
Tbio
Novelty: 0.00042077
Score: 0.968
Data Source: STRINGDB
SLC40A1
Tchem
Family: Transporter
Novelty: 0.00222468
Score: 0.965
Data Source: STRINGDB
TMPRSS6
Tchem
Family: Enzyme
Novelty: 0.00739906
Score: 0.94
Data Source: STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
Score: 0.921
Data Source: STRINGDB
SLC11A2
Tchem
Family: Transporter
Novelty: 0.00189409
Score: 0.914
Data Source: STRINGDB
CREB3L3
Tbio
Family: TF
Novelty: 0.02519904
Score: 0.904
Data Source: STRINGDB
EPO
Tbio
Novelty: 0.00013701
Score: 0.902
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.892
Data Source: STRINGDB
Publication Statistics
PubMed Score  3334.95

PubMed score by year
PubTator Score  1718.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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