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Tchem
FPR1
fMet-Leu-Phe receptor

Protein Summary
Description
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304748
  • ENSP00000302707
  • ENSG00000171051
  • ENST00000595042
  • ENSP00000471493

Symbol
  • FPR
  • FMLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
ligand (chemical)
0.93
hub protein
0.67
cell type or tissue
0.66
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.99   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.99   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
1
1
48.2
eosinophil percentage of leukocytes
1
1
1
40.3
eosinophil count
1
1
1
39.6
high density lipoprotein cholesterol measurement
1
1
1
37.5
lymphocyte count
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
48.2
eosinophil percentage of leukocytes
1
40.3
eosinophil count
1
39.6
high density lipoprotein cholesterol measurement
1
37.5
lymphocyte count
1
15.1
Pathways (22)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
Formyl peptide receptors bind formyl peptides and many other ligands
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
Formyl peptide receptors bind formyl peptides and many other ligands
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (368)
1 – 10 of 368
ANXA1
Tbio
Novelty: 0.00103537
Score: 0.988
Data Source: STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
Score: 0.967
Data Source: STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.962
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.962
Data Source: STRINGDB
C5AR1
Tchem
Family: GPCR
Novelty: 0.00188281
Score: 0.957
Data Source: STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.957
Data Source: STRINGDB
SAA1
Tbio
Novelty: 0.0006102
Score: 0.951
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.95
Data Source: STRINGDB
NPY5R
Tchem
Family: GPCR
Novelty: 0.01747655
Score: 0.95
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  414.99

PubMed score by year
PubTator Score  2668.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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