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Tbio
MYO9B
Unconventional myosin-IXb

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397274
  • ENSP00000380444
  • ENSG00000099331
  • ENST00000595618
  • ENSP00000471457

Symbol
  • MYR5
  • MYR5
  • CELIAC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.99
drug perturbation
0.99
protein domain
0.99
co-expressed gene
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.24   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.24   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
6
92.9
body height
3
3
3
90.1
mean platelet volume
3
2
3
88.8
platelet count
4
4
5
87.6
mean corpuscular hemoglobin concentration
3
4
4
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
92.9
body height
3
90.1
mean platelet volume
3
88.8
platelet count
5
87.6
mean corpuscular hemoglobin concentration
4
82.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin IXB
VGNC:13235
107966213
Macaque
myosin IXB
719690
Mouse
MGI:106624
17925
Rat
RGD:3146
25486
Dog
myosin IXB
VGNC:43575
484844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin IXB
Macaque
myosin IXB
Mouse
Rat
Dog
myosin IXB
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13459-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Gene Ontology Terms (23)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (106)
1 – 10 of 106
SDF4
Tbio
Novelty: 0.00105893
p_int: 0.985343287
p_ni: 0.014656713
Score: 0.198
Data Source: BioPlex,STRINGDB
DQX1
Tdark
Family: Enzyme
Novelty: 1.01984582
p_int: 0.981764403
p_ni: 0.018235597
Score: 0.186
Data Source: BioPlex,STRINGDB
FAM131B
Tdark
Novelty: 0.3424123
p_int: 0.94640218
p_ni: 0.05359782
Data Source: BioPlex
EID1
Tbio
Novelty: 0.02414732
p_int: 0.939520666
p_ni: 0.060479334
Score: 0.167
Data Source: BioPlex,STRINGDB
MOAP1
Tbio
Novelty: 0.05070263
p_int: 0.901950213
p_ni: 0.098049787
Score: 0.189
Data Source: BioPlex,STRINGDB
RBM33
Tdark
Novelty: 0.1482404
p_int: 0.894954313
p_ni: 0.105045687
Score: 0.241
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.88368493
p_ni: 0.11631507
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.878137983
p_ni: 0.121862017
Score: 0.26
Data Source: BioPlex,STRINGDB
IFT43
Tbio
Novelty: 0.00478274
p_int: 0.865650691
p_ni: 0.134349309
Score: 0.183
Data Source: BioPlex,STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
p_int: 0.848872603
p_ni: 0.151127397
Data Source: BioPlex
Publication Statistics
PubMed Score  69.24

PubMed score by year
PubTator Score  49.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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