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Tbio
IL12RB1
Interleukin-12 receptor subunit beta-1

Protein Summary
Description
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322153
  • ENSP00000314425
  • ENSG00000096996
  • ENST00000593993
  • ENSP00000472165
  • ENST00000600835
  • ENSP00000470788

Symbol
  • IL12R
  • IL12RB
  • CD212
  • IMD30
  • IL12RB
  • IL-12R-BETA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
tissue sample
0.73
disease
0.66
cell type or tissue
0.63
tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.31   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 432   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.31   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
95.7
2
2
0
1.3
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
95.7
0
1.3
67.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 12 receptor subunit beta 1
VGNC:6633
455851
Macaque
interleukin 12 receptor subunit beta 1
574199
Mouse
MGI:104579
16161
Rat
RGD:620025
171333
Dog
interleukin 12 receptor subunit beta 1
VGNC:41934
484828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 12 receptor subunit beta 1
Macaque
interleukin 12 receptor subunit beta 1
Mouse
Rat
Dog
interleukin 12 receptor subunit beta 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P42701-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (146)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Reactome
Interleukin-23 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Interleukin-23 signaling
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (155)
1 – 10 of 155
TXNIP
Tbio
Novelty: 0.00216952
p_int: 0.996781174
p_ni: 0.000767372
p_wrong: 0.002451454
Score: 0.237
Data Source: BioPlex,STRINGDB
ISOC2
Tbio
Family: Enzyme
Novelty: 0.33841868
p_int: 0.977903122
p_ni: 0.015548749
p_wrong: 0.00654813
Score: 0.237
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.966949359
p_ni: 0.033050641
Data Source: BioPlex
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.935821211
p_ni: 0.064178789
Data Source: BioPlex
LOXL2
Tbio
Family: Enzyme
Novelty: 0.00599536
p_int: 0.92599446
p_ni: 0.008532161
p_wrong: 0.065473379
Score: 0.158
Data Source: BioPlex,STRINGDB
CBWD1
Tbio
Novelty: 0.04321511
p_int: 0.893272911
p_ni: 0.106727078
p_wrong: 1.1e-8
Score: 0.513
Data Source: BioPlex,STRINGDB
NPTX1
Tbio
Novelty: 0.02872516
p_int: 0.887008825
p_ni: 0.112990943
p_wrong: 2.32e-7
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.852525843
p_ni: 0.147474157
Data Source: BioPlex
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.831559297
p_ni: 0.168440703
Data Source: BioPlex
TRMT44
Tdark
Family: Enzyme
Novelty: 0.27902923
p_int: 0.807074538
p_ni: 0.192921918
p_wrong: 0.000003543
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  257.31

PubMed score by year
PubTator Score  154.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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