Tbio MYH14 Myosin-14

Protein Summary

Description

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q7Z406
• B0I1S2
• C3TTN4
• Q5CZ75
• Q6XYE4
• Q76B62
• Q8WV23
• Q96I22
• Q9BT27
• Q9BW35
• Q9H882

Gene Name

• MYH14

Ensembl ID

• ENST00000376970
• ENSP00000366169
• ENSG00000105357
• ENST00000425460
• ENSP00000407879
• ENST00000596571
• ENSP00000472819
• ENST00000598205
• ENSP00000472543
• ENST00000601313
• ENSP00000470298
• ENST00000642316
• ENSP00000493594

Symbol

• KIAA2034
• DFNA4
• MHC16
• MYH17
• PNMHH
• DFNA4A
• myosin
• FP17425
• NMHC II-C
• NMHC-II-C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
interacting protein	0.95
cellular component	0.79
protein domain	0.73
disease perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.89   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.89   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (19)

Reactome (14)

KEGG (2)

PathwayCommons (3)

Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPHA-mediated growth cone collapse	15 targets	R-HSA-3928663
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPHA-mediated growth cone collapse	15 targets	R-HSA-3928663
RHO GTPase Effectors	273 targets	R-HSA-195258

Gene Ontology Terms (25)

Functions (6)

Components (10)

Processes (9)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
ATPase activity	Inferred from Direct Assay (IDA)	UniProtKB
actin filament binding	Inferred from Electronic Annotation (IEA)	Ensembl
actin-dependent ATPase activity	Inferred from Electronic Annotation (IEA)	Ensembl
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
microfilament motor activity	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (144)

Explore Interacting Targets

1 – 10 of 144

• See Interactions on String-DB

MYL12B

Tbio

Novelty: 0.01158157

p_int: 0.999919198

p_ni: 0.000080802

Score: 0.98

Data Source: BioPlex,Reactome,STRINGDB

S100A4

Tbio

Novelty: 0.00156469

p_int: 0.999726321

p_ni: 0.000273679

Score: 0.155

Data Source: BioPlex,STRINGDB

MYL6

Tbio

Novelty: 0.00785422

p_int: 0.999636342

p_ni: 0.000363659

Score: 0.984

Data Source: BioPlex,Reactome,STRINGDB

MYL3

Tbio

Novelty: 0.00661146

p_int: 0.984588129

p_ni: 0.015411871

Score: 0.959

Data Source: BioPlex,STRINGDB

UNC45A

Tbio

Novelty: 0.02364465

p_int: 0.942855458

p_ni: 0.057144542

Score: 0.655

Data Source: BioPlex,STRINGDB

FCF1

Tdark

Novelty: 0.00913312

p_int: 0.897727394

p_ni: 0.102272606

Data Source: BioPlex

MYL9

Tbio

Novelty: 0.00271264

Score: 0.983

Data Source: Reactome,STRINGDB

MYLK

Tchem

Family: Kinase

Novelty: 0.00132404

Score: 0.952

Data Source: Reactome,STRINGDB

MYL5

Tbio

Novelty: 0.01562031

Score: 0.95

Data Source: STRINGDB

MYL6B

Tbio

Novelty: 0.01751395

Score: 0.947

Data Source: STRINGDB

Publication Statistics

PubMed Score  76.89

PubMed score by year

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PubTator Score  8606.95

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGGGPGSGTSPQVEWTARRLVWVPSELHGFEAAAL

1-70

RDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGL

70-140

FCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKK

140-210

VIQYLAHVASSPKGRKEPGVPGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIVGAN

210-280

IETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLE

280-350

SLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKLCRLLGLGVTDFSRALLTPRI

350-420

KVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSF

420-490

EQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWF

490-560

PKATDKSFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQST

560-630

DRLTAEIWKDVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNH

630-700

EKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQA

700-770

LELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNC

770-840

AAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLA

840-910

EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE

910-980

GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE

980-1050

ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG

1050-1120

GARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE

1120-1190

QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL

1190-1260

QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST

1260-1330

EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEE

1330-1400

AGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKF

1400-1470

DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV

1470-1540

GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ

1540-1610

LAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE

1610-1680

TRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQ

1680-1750

LEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGE

1750-1820

EDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLE

1820-1890

KGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQV

1890-1960

FRLEEGVASDEEAEEAQPGSGPSPEPEGSPPAHPQ

1960-1995

MAAVTMSVPGRKAPPRPGPVPEAAQPFLFTPRGPSAGGGPGSGTSPQVEWTARRLVWVPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPGQERELFQETLESLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDQATMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSPPAHPQ

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
ATP-binding
Calmodulin-binding
Cell shape
Coiled coil
Complete proteome
Deafness