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Tbio
DTNA
Dystrobrevin alpha

Protein Summary
Description
May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269192
  • ENSP00000269192
  • ENSG00000134769
  • ENST00000283365
  • ENSP00000283365
  • ENST00000315456
  • ENSP00000322519
  • ENST00000348997
  • ENSP00000336682
  • ENST00000399113
  • ENSP00000382064
  • ENST00000399121
  • ENSP00000382072
  • ENST00000444659
  • ENSP00000405819
  • ENST00000554864
  • ENSP00000451516
  • ENST00000556414
  • ENSP00000452255
  • ENST00000591182
  • ENSP00000467720
  • ENST00000595022
  • ENSP00000473078
  • ENST00000596745
  • ENSP00000469121
  • ENST00000597599
  • ENSP00000473119
  • ENST00000597674
  • ENSP00000471783
  • ENST00000598142
  • ENSP00000470716
  • ENST00000598334
  • ENSP00000470152
  • ENST00000598774
  • ENSP00000472031

Symbol
  • DRP3
  • DTN
  • DRP3
  • DTN-A
  • LVNC1
  • D18S892E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.96
microRNA
0.92
transcription factor
0.87
PubMedID
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.61   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.61   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
90.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dystrobrevin alpha
VGNC:5162
455367
Macaque
dystrobrevin alpha
707887
Mouse
MGI:106039
13527
Rat
RGD:1561985
307548
Dog
dystrobrevin alpha
VGNC:40114
490488
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dystrobrevin alpha
Macaque
dystrobrevin alpha
Mouse
Rat
Dog
dystrobrevin alpha
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y4J8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (95)
1 – 10 of 95
DMD
Tclin
Novelty: 0.00025661
p_int: 0.999999995
p_ni: 5e-9
Score: 0.738
Data Source: BioPlex,STRINGDB
SNTG1
Tbio
Novelty: 0.05608114
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.841
Data Source: BioPlex,STRINGDB
SNTG2
Tbio
Novelty: 0.04056715
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.9
Data Source: BioPlex,STRINGDB
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.999996078
p_ni: 0.000003921
Score: 0.424
Data Source: BioPlex,STRINGDB
RPP25L
Tdark
Family: Enzyme
Novelty: 1.39761189
p_int: 0.999891191
p_ni: 0.000108784
p_wrong: 2.5e-8
Data Source: BioPlex
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.999870429
p_ni: 0.000129571
Score: 0.828
Data Source: BioPlex,STRINGDB
TAGAP
Tbio
Family: Enzyme
Novelty: 0.04450409
p_int: 0.999803303
p_ni: 0.000196669
p_wrong: 2.8e-8
Data Source: BioPlex
POTEI
Tdark
Novelty: 0.41311202
p_int: 0.999751998
p_ni: 0.000248002
Score: 0.198
Data Source: BioPlex,STRINGDB
COG6
Tbio
Novelty: 0.02874093
p_int: 0.998080086
p_ni: 0.001919914
Data Source: BioPlex
FYCO1
Tbio
Novelty: 0.06181219
p_int: 0.997987777
p_ni: 0.002010497
p_wrong: 0.000001726
Score: 0.65
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  77.61

PubMed score by year
PubTator Score  9.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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