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Tbio
NOSIP
Nitric oxide synthase-interacting protein

Protein Summary
Description
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000596358
  • ENSP00000470034
  • ENSG00000142546

Symbol
  • CGI-25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
disease perturbation
0.83
transcription factor binding site profile
0.83
tissue
0.7
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
86.3
hematocrit
3
2
3
85.8
erythrocyte count
1
1
1
28.6
2
1
0
1.1
28.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
86.3
hematocrit
3
85.8
erythrocyte count
1
28.6
0
1.1
28.5
Pathways (3)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
NOSIP mediated eNOS trafficking
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nitric oxide: eNOS activation and regulation
NOSIP mediated eNOS trafficking
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
TNNC2
Tbio
Novelty: 0.07759506
p_int: 0.998085612
p_ni: 0.000001806
p_wrong: 0.001912582
Score: 0.381
Data Source: BioPlex,STRINGDB
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.946300082
p_ni: 0.053699918
Score: 0.158
Data Source: BioPlex,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
p_int: 0.830797037
p_ni: 0.169199775
p_wrong: 0.000003188
Data Source: BioPlex
NEU2
Tbio
Family: Enzyme
Novelty: 0.00460828
p_int: 0.802539554
p_ni: 0.197334528
p_wrong: 0.000125918
Score: 0.189
Data Source: BioPlex,STRINGDB
POLL
Tbio
Family: Enzyme
Novelty: 0.00244645
p_int: 0.801339938
p_ni: 0.198660043
p_wrong: 2e-8
Score: 0.2
Data Source: BioPlex,STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.98
Data Source: Reactome,STRINGDB
RCN3
Tbio
Novelty: 0.18065025
Score: 0.771
Data Source: STRINGDB
NOSTRIN
Tbio
Novelty: 0.05720571
Score: 0.737
Data Source: STRINGDB
PRRG2
Tbio
Novelty: 0.16164794
Score: 0.698
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.673
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.73

PubMed score by year
PubTator Score  7.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer