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Tbio
SHANK2
SH3 and multiple ankyrin repeat domains protein 2

Protein Summary
Description
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409530
  • ENSP00000387324
  • ENSG00000162105
  • ENST00000601538
  • ENSP00000469689

Symbol
  • CORTBP1
  • KIAA1022
  • PROSAP1
  • SHANK
  • AUTS17
  • CORTBP1
  • CTTNBP1
  • ProSAP1
  • SPANK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
protein domain
0.85
cellular component
0.75
disease perturbation
0.74
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.41   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.41   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
2
2
94.2
unipolar depression
1
1
0
1
89.3
1
1
0
1.1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
94.2
unipolar depression
0
1
89.3
0
1.1
15.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 and multiple ankyrin repeat domains 2
VGNC:13317
466694
Macaque
SH3 and multiple ankyrin repeat domains 2
708192
Mouse
MGI:2671987
210274
Rat
RGD:628772
171093
Rat
RGD:9143352
103690160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 and multiple ankyrin repeat domains 2
Macaque
SH3 and multiple ankyrin repeat domains 2
Mouse
Rat
Rat
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UPX8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (35)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (115)
1 – 10 of 115
NLK
Tchem
Family: Kinase
Novelty: 0.01512201
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.461
Data Source: BioPlex,STRINGDB
DLGAP2
Tbio
Novelty: 0.02137009
Score: 0.995
Data Source: Reactome,STRINGDB
DLGAP1
Tbio
Novelty: 0.01576595
Score: 0.994
Data Source: Reactome,STRINGDB
DLGAP3
Tbio
Novelty: 0.02019435
Score: 0.991
Data Source: Reactome,STRINGDB
DLGAP4
Tbio
Novelty: 0.06240351
Score: 0.988
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.982
Data Source: Reactome,STRINGDB
NLGN4X
Tbio
Family: Enzyme
Novelty: 0.01004489
Score: 0.976
Data Source: STRINGDB
NLGN3
Tbio
Family: Enzyme
Novelty: 0.00819625
Score: 0.976
Data Source: STRINGDB
NRXN1
Tbio
Novelty: 0.00454659
Score: 0.975
Data Source: STRINGDB
NRXN1
Tbio
Novelty: 0.00454659
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  154.41

PubMed score by year
PubTator Score  827

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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