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Tbio
KANK2
KN motif and ankyrin repeat domain-containing protein 2

Protein Summary
Description
Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). This gene encodes a member of the KN motif and ankyrin repeat domai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000586659
  • ENSP00000465650
  • ENSG00000197256
  • ENST00000589359
  • ENSP00000468002
  • ENST00000589894
  • ENSP00000467029

Symbol
  • ANKRD25
  • KIAA1518
  • MXRA3
  • SIP
  • SIP
  • MXRA3
  • PPKWH
  • NPHS16
  • ANKRD25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
co-expressed gene
0.85
ligand (protein) perturbation
0.83
biological process
0.79
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
5
9
84.8
red blood cell distribution width
3
3
3
83.6
reticulocyte measurement
3
5
6
78.7
apolipoprotein B measurement
1
1
1
35.4
total cholesterol measurement
1
1
1
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
84.8
red blood cell distribution width
3
83.6
reticulocyte measurement
6
78.7
apolipoprotein B measurement
1
35.4
total cholesterol measurement
1
34.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (72)
1 – 10 of 72
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.998276862
p_ni: 0.001723138
Data Source: BioPlex
SRSF2
Tbio
Novelty: 0.00207072
p_int: 0.967351132
p_ni: 0.032648868
Data Source: BioPlex
PROZ
Tbio
Family: Enzyme
Novelty: 0.05629679
p_int: 0.904968501
p_ni: 0.095031499
Score: 0.191
Data Source: BioPlex,STRINGDB
PPFIBP1
Tbio
Novelty: 0.09685089
p_int: 0.875170604
p_ni: 0.124829396
Score: 0.471
Data Source: BioPlex,STRINGDB
TMOD4
Tbio
Novelty: 0.00932697
p_int: 0.824302434
p_ni: 0.175697566
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.803121912
p_ni: 0.196878088
Data Source: BioPlex
SKP2
Tbio
Family: Enzyme
Novelty: 0.00182658
p_int: 0.795044707
p_ni: 0.204955293
Data Source: BioPlex
THSD4
Tbio
Novelty: 0.12898073
p_int: 0.790691272
p_ni: 0.209308728
Score: 0.21
Data Source: BioPlex,STRINGDB
BBS7
Tbio
Novelty: 0.03611111
p_int: 0.750504784
p_ni: 0.249495216
Data Source: BioPlex
KIF21A
Tbio
Novelty: 0.01535562
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.72

PubMed score by year
PubTator Score  8.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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