You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNNT1
Troponin T, slow skeletal muscle

Protein Summary
Description
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291901
  • ENSP00000291901
  • ENSG00000105048
  • ENST00000356783
  • ENSP00000349233
  • ENST00000587758
  • ENSP00000467789
  • ENST00000588981
  • ENSP00000467176

Symbol
  • TNT
  • ANM
  • TNT
  • NEM5
  • STNT
  • TNTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.81
small molecule perturbation
0.75
cell type or tissue
0.56
cellular component
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1372.42   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1372.42   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
11.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
troponin T1, slow skeletal type
698339
Mouse
MGI:1333868
21955
Rat
RGD:621852
171409
Dog
troponin T1, slow skeletal type
VGNC:47690
476383
Horse
troponin T1, slow skeletal type
VGNC:24392
100055363
Species
Name
OMA
EggNOG
Inparanoid
Macaque
troponin T1, slow skeletal type
Mouse
Rat
Dog
troponin T1, slow skeletal type
Horse
troponin T1, slow skeletal type
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P13805-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (114)
1 – 10 of 114
TLK1
Tchem
Family: Kinase
Novelty: 0.0342719
p_int: 0.999792249
p_ni: 0.000207736
p_wrong: 1.6e-8
Data Source: BioPlex
PRKG1
Tchem
Family: Kinase
Novelty: 0.0014943
p_int: 0.998406196
p_ni: 0.001593803
p_wrong: 1e-9
Score: 0.496
Data Source: BioPlex,STRINGDB
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.986659098
p_ni: 0.012381566
p_wrong: 0.000959336
Data Source: BioPlex
TJP2
Tbio
Novelty: 0.00446681
p_int: 0.97750096
p_ni: 0.022447889
p_wrong: 0.000051151
Data Source: BioPlex
CDK5RAP2
Tbio
Novelty: 0.00956263
p_int: 0.970795112
p_ni: 0.029204885
p_wrong: 4e-9
Data Source: BioPlex
ARMC8
Tbio
Novelty: 0.06820746
p_int: 0.940415255
p_ni: 0.059584745
Data Source: BioPlex
TLK2
Tchem
Family: Kinase
Novelty: 0.07082609
p_int: 0.936482399
p_ni: 0.063517532
p_wrong: 6.9e-8
Data Source: BioPlex
GID4
Tbio
Novelty: 0.05252674
p_int: 0.907939284
p_ni: 0.092060716
Data Source: BioPlex
TPM1
Tbio
Novelty: 0.00261206
p_int: 0.868820225
p_ni: 0.131179776
Score: 0.985
Data Source: BioPlex,STRINGDB
MAEA
Tbio
Novelty: 0.00833813
p_int: 0.843167036
p_ni: 0.156832964
Data Source: BioPlex
Publication Statistics
PubMed Score  1372.42

PubMed score by year
PubTator Score  661.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer