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Tbio
TTN
Titin

Protein Summary
Description
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobu ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
interacting protein
0.99
trait
0.93
biological process
0.91


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2554.3   (req: < 5)
Gene RIFs: 165   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2554.3   (req: >= 5)
Gene RIFs: 165   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
93.8
left ventricular structural measurement
2
1
2
69
2
1
2
58
electrocardiography
1
1
2
53.3
QT interval
1
1
0
1.9
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
93.8
left ventricular structural measurement
2
69
2
58
electrocardiography
2
53.3
QT interval
0
1.9
32.7
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98864
22138
Dog
titin
VGNC:53109
478820
Horse
titin
VGNC:51493
100053844
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
titin
Horse
titin
Protein Structure (40 Structures, 166 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 40
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Muscle contraction
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Muscle contraction
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (265)
1 – 10 of 265
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.999998964
p_ni: 0.000001036
Data Source: BioPlex
TLE3
Tbio
Novelty: 0.02641884
p_int: 0.999998429
p_ni: 0.00000157
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.999992173
p_ni: 0.000007827
Data Source: BioPlex
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.99998445
p_ni: 0.00001555
Data Source: BioPlex
ADAM2
Tbio
Family: Enzyme
Novelty: 0.00586482
p_int: 0.886070245
p_ni: 0.104480554
p_wrong: 0.009449201
Score: 0.426
Data Source: BioPlex,STRINGDB
NEB
Tbio
Novelty: 0.00174728
Score: 0.999
Data Source: STRINGDB
TCAP
Tbio
Novelty: 0.00623581
Score: 0.998
Data Source: STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
Score: 0.995
Data Source: STRINGDB
MYL1
Tbio
Novelty: 0.00360262
Score: 0.994
Data Source: Reactome,STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  2554.30

PubMed score by year
PubTator Score  1157.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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