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Tbio
MUM1
PWWP domain-containing protein MUM1

Protein Summary
Description
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311401
  • ENSP00000309135
  • ENSG00000160953
  • ENST00000415183
  • ENSP00000394925

Symbol
  • EXPAND1
  • MUM1
  • MUM-1
  • EXPAND1
  • HSPC211
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cell type or tissue
0.74
histone modification site profile
0.72
tissue sample
0.65
tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (29)
1 – 10 of 29
EVPL
Tbio
Novelty: 0.00274279
p_int: 0.9990895
p_ni: 0.0009105
Data Source: BioPlex
BAIAP2L1
Tbio
Novelty: 0.06381886
p_int: 0.998496153
p_ni: 0.001503752
p_wrong: 9.5e-8
Score: 0.416
Data Source: BioPlex,STRINGDB
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.997502592
p_ni: 0.002493743
p_wrong: 0.000003665
Data Source: BioPlex
EPPK1
Tdark
Novelty: 0.03621061
p_int: 0.99658998
p_ni: 0.00341002
Data Source: BioPlex
SERPINB4
Tbio
Novelty: 0.00522283
p_int: 0.993449031
p_ni: 0.006550969
Data Source: BioPlex
SERPINB5
Tbio
Novelty: 0.00192585
p_int: 0.988523784
p_ni: 0.011475925
p_wrong: 2.91e-7
Data Source: BioPlex
PPL
Tbio
Novelty: 0.00684645
p_int: 0.987793399
p_ni: 0.012206582
p_wrong: 1.9e-8
Data Source: BioPlex
IVL
Tbio
Novelty: 0.00147892
p_int: 0.98049267
p_ni: 0.019507317
p_wrong: 1.3e-8
Data Source: BioPlex
IGHG2
Tdark
p_int: 0.97686818
p_ni: 0.022005198
p_wrong: 0.001126622
Data Source: BioPlex
SERPINB1
Tbio
Family: Enzyme
Novelty: 0.00267786
p_int: 0.970554548
p_ni: 0.02910408
p_wrong: 0.000341372
Data Source: BioPlex
Publication Statistics
PubMed Score  6.29

PubMed score by year
PubTator Score  113.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer