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Tclin
ELANE
Neutrophil elastase

Protein Summary
Description
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263621
  • ENSP00000263621
  • ENSG00000197561
  • ENST00000590230
  • ENSP00000466090
  • ENST00000615489
  • ENSP00000480128
  • ENSG00000277571
  • ENST00000632488
  • ENSP00000488075

Symbol
  • ELA2
  • GE
  • NE
  • HLE
  • HNE
  • ELA2
  • SCN1
  • PMN-E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.98
molecular function
0.9
cellular component
0.75
gene perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3468.91   (req: < 5)
Gene RIFs: 194   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3468.91   (req: >= 5)
Gene RIFs: 194   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1574
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Antimicrobial peptides
Reactome
Collagen degradation
Reactome
Complement cascade
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Antimicrobial peptides
Collagen degradation
Complement cascade
Degradation of the extracellular matrix
Gene Ontology Terms (44)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (304)
1 – 10 of 304
SLPI
Tbio
Family: Enzyme
Novelty: 0.00194459
Score: 0.997
Data Source: STRINGDB
MPO
Tchem
Family: Enzyme
Novelty: 0.00020698
Score: 0.995
Data Source: STRINGDB
DEFA4
Tbio
Novelty: 0.04566082
Score: 0.987
Data Source: STRINGDB
BPI
Tbio
Novelty: 0.00229665
Score: 0.982
Data Source: STRINGDB
CTSG
Tchem
Family: Enzyme
Novelty: 0.00102052
Score: 0.982
Data Source: STRINGDB
CAMP
Tbio
Novelty: 0.00064433
Score: 0.98
Data Source: STRINGDB
AZU1
Tbio
Family: Enzyme
Novelty: 0.00267169
Score: 0.979
Data Source: STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00059878
Score: 0.977
Data Source: STRINGDB
MMP8
Tchem
Family: Enzyme
Novelty: 0.00105859
Score: 0.967
Data Source: STRINGDB
GRN
Tbio
Novelty: 0.00096395
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  3468.91

PubMed score by year
PubTator Score  2220.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer