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Tbio
GALK1
Galactokinase

Protein Summary
Description
Major enzyme for galactose metabolism. Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225614
  • ENSP00000225614
  • ENSG00000108479
  • ENST00000588479
  • ENSP00000465930

Symbol
  • GALK
  • GK1
  • GALK
  • HEL-S-19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.94
molecular function
0.94
small molecule perturbation
0.8
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.02   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.02   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
61.2
leukocyte count
1
1
1
13.8
apolipoprotein B measurement
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
61.2
leukocyte count
1
13.8
apolipoprotein B measurement
1
2.4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Defective GALK1 can cause Galactosemia II (GALCT2) (R-HSA-5609976)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective GALK1 can cause Galactosemia II (GALCT2)
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Reactome
Diseases of glycosylation
Reactome
Galactose catabolism
Name
Explore in Pharos
Explore in Source
Defective GALK1 can cause Galactosemia II (GALCT2)
Disease
Diseases associated with glycosylation precursor biosynthesis
Diseases of glycosylation
Galactose catabolism
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (105)
1 – 10 of 105
GALT
Tbio
Family: Enzyme
Novelty: 0.0120291
Score: 0.999
Data Source: STRINGDB
GALM
Tbio
Family: Enzyme
Novelty: 0.01067063
Score: 0.998
Data Source: STRINGDB
GALE
Tchem
Family: Enzyme
Novelty: 0.00256798
Score: 0.988
Data Source: STRINGDB
MVK
Tchem
Family: Kinase
Novelty: 0.00328607
Score: 0.853
Data Source: STRINGDB
TK1
Tchem
Family: Kinase
Novelty: 0.00139343
Score: 0.799
Data Source: STRINGDB
UGP2
Tbio
Family: Enzyme
Novelty: 0.00760963
Score: 0.757
Data Source: STRINGDB
DHDH
Tbio
Family: Enzyme
Novelty: 0.00284827
Score: 0.75
Data Source: STRINGDB
UGDH
Tbio
Family: Enzyme
Novelty: 0.00284931
Score: 0.713
Data Source: STRINGDB
SLC35A2
Tbio
Family: Transporter
Novelty: 0.00072521
Score: 0.677
Data Source: STRINGDB
LCT
Tbio
Family: Enzyme
Novelty: 0.0019382
Score: 0.672
Data Source: STRINGDB
Publication Statistics
PubMed Score  635.02

PubMed score by year
PubTator Score  270.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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