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Tbio
COASY
Bifunctional coenzyme A synthase

Protein Classes
Protein Summary
Description
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393818
  • ENSP00000377406
  • ENSG00000068120
  • ENST00000421097
  • ENSP00000393564
  • ENST00000590958
  • ENSP00000464814

Symbol
  • NBP
  • DPCK
  • PPAT
  • UKR1
  • NBIA6
  • PCH12
  • pOV-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
molecular function
0.94
disease perturbation
0.87
interacting protein
0.87
transcription factor binding site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.12   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.12   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Drugs used in diabetes use measurement
1
1
1
14.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Drugs used in diabetes use measurement
1
14.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Coenzyme A synthase
VGNC:9242
454690
Macaque
Coenzyme A synthase
710491
Mouse
MGI:1918993
71743
Rat
RGD:1549767
287711
Dog
Coenzyme A synthase
VGNC:51942
480517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Coenzyme A synthase
Macaque
Coenzyme A synthase
Mouse
Rat
Dog
Coenzyme A synthase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13057-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Coenzyme A biosynthesis (R-HSA-196783)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Coenzyme A biosynthesis
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B5 (pantothenate) metabolism
Name
Explore in Pharos
Explore in Source
Coenzyme A biosynthesis
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B5 (pantothenate) metabolism
Protein-Protein Interactions (215)
1 – 10 of 215
HEPHL1
Tbio
Novelty: 0.44678065
p_int: 0.999414786
p_ni: 0.000585214
Score: 0.157
Data Source: BioPlex,STRINGDB
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.994134348
p_ni: 0.005865652
Data Source: BioPlex
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.989388979
p_ni: 0.010611021
Data Source: BioPlex
S100A3
Tbio
Novelty: 0.03024004
p_int: 0.984760538
p_ni: 0.000294814
p_wrong: 0.014944648
Score: 0.193
Data Source: BioPlex,STRINGDB
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.974654859
p_ni: 0.025345141
Score: 0.166
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.952691376
p_ni: 0.047308623
p_wrong: 1e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.918794655
p_ni: 0.081182359
p_wrong: 0.000022986
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.915988338
p_ni: 0.084011662
Data Source: BioPlex
HIST1H2AG
Tbio
Novelty: 0.03331195
p_int: 0.79286926
p_ni: 0.20713074
Data Source: BioPlex
PPCDC
Tbio
Family: Enzyme
Novelty: 0.0322534
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  301.12

PubMed score by year
PubTator Score  32.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer