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Tchem
KCNJ12
ATP-sensitive inward rectifier potassium channel 12

Protein Summary
Description
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is locat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331718
  • ENSP00000328150
  • ENSG00000184185
  • ENST00000583088
  • ENSP00000463778

Symbol
  • IRK2
  • KCNJN1
  • IRK2
  • hIRK
  • IRK-2
  • hIRK1
  • KCNJN1
  • Kir2.2
  • Kir2.2v
  • kcnj12x
  • hkir2.2x
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
protein domain
0.73
tissue sample
0.65
cell type or tissue
0.62
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.61   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.61   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
69.7
body height
2
2
2
69
reticulocyte measurement
3
2
3
54.3
1
1
1
43.4
waist-hip ratio
1
1
1
20.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
69.7
body height
2
69
reticulocyte measurement
3
54.3
1
43.4
waist-hip ratio
1
20.4
Pathways (17)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Cardiac conduction
Reactome
Classical Kir channels
Reactome
G protein gated Potassium channels
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Cardiac conduction
Classical Kir channels
G protein gated Potassium channels
Protein-Protein Interactions (83)
1 – 10 of 83
GNB2
Tbio
Novelty: 0.08682553
Score: 0.939
Data Source: Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.939
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.938
Data Source: Reactome,STRINGDB
GNG8
Tdark
Novelty: 0.00590503
Score: 0.913
Data Source: STRINGDB
GNG7
Tbio
Novelty: 0.08478455
Score: 0.912
Data Source: STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.91
Data Source: STRINGDB
GABBR2
Tclin
Family: GPCR
Novelty: 0.00739771
Score: 0.909
Data Source: Reactome,STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.906
Data Source: STRINGDB
KCNJ2
Tchem
Family: IC
Novelty: 0.00290395
Score: 0.905
Data Source: Reactome,STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.905
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  114.61

PubMed score by year
PubTator Score  65.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer