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Tbio
SEC22B
Vesicle-trafficking protein SEC22b

Protein Summary
Description
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000578049
  • ENSP00000463393
  • ENSG00000265808

Symbol
  • SEC22L1
  • ERS-24
  • SEC22L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.91
transcription factor perturbation
0.8
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPII-mediated vesicle transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPII-mediated vesicle transport
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (251)
1 – 10 of 251
USE1
Tbio
Novelty: 0.00904756
p_int: 0.9999977
p_ni: 0.0000023
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
SCFD2
Tdark
Novelty: 0.38252131
p_int: 0.999997057
p_ni: 0.000002943
Score: 0.834
Data Source: BioPlex,STRINGDB
NBAS
Tbio
Novelty: 0.01187862
p_int: 0.999995993
p_ni: 0.000004007
Score: 0.982
Data Source: BioPlex,STRINGDB
STX18
Tbio
Novelty: 0.0259034
p_int: 0.999947318
p_ni: 0.000052682
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
RINT1
Tbio
Novelty: 0.04546291
p_int: 0.999943075
p_ni: 0.000056925
Score: 0.991
Data Source: BioPlex,STRINGDB
BNIP1
Tbio
Novelty: 0.04601895
p_int: 0.999932207
p_ni: 0.000067793
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
BET1
Tdark
Novelty: 0.01791164
p_int: 0.999922949
p_ni: 0.000076954
p_wrong: 9.7e-8
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
STX5
Tbio
Novelty: 0.00964918
p_int: 0.999864755
p_ni: 0.000135245
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
GOSR1
Tbio
Novelty: 0.03139481
p_int: 0.999811668
p_ni: 0.000188332
Score: 0.995
Data Source: BioPlex,STRINGDB
GOSR2
Tbio
Novelty: 0.02447711
p_int: 0.999808827
p_ni: 0.000189857
p_wrong: 0.000001316
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  34.58

PubMed score by year
PubTator Score  13.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer