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Tbio
TXNIP
Thioredoxin-interacting protein

Protein Summary
Description
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative func ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425134
  • ENSP00000396322
  • ENSG00000265972
  • ENST00000582401
  • ENSP00000462521

Symbol
  • VDUP1
  • THIF
  • VDUP1
  • ARRDC6
  • HHCPA78
  • EST01027
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.99
gene perturbation
0.98
transcription factor perturbation
0.98
kinase perturbation
0.97
PubMedID
0.96


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 619.31   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 619.31   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin interacting protein
457986
Macaque
thioredoxin interacting protein
698683
Mouse
MGI:1889549
56338
Rat
RGD:620886
117514
Dog
thioredoxin interacting protein
VGNC:48017
475829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin interacting protein
Macaque
thioredoxin interacting protein
Mouse
Rat
Dog
thioredoxin interacting protein
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H3M7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (109)
FOXO-mediated transcription (R-HSA-9614085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FOXO-mediated transcription
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Inflammasomes
Name
Explore in Pharos
Explore in Source
FOXO-mediated transcription
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Inflammasomes
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (125)
1 – 10 of 125
S100A4
Tbio
Novelty: 0.00136919
p_int: 0.999984834
p_ni: 0.000015029
p_wrong: 1.36e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00519213
p_int: 0.999262698
p_ni: 0.000737302
Data Source: BioPlex
DCAF16
Tdark
Novelty: 0.35666992
p_int: 0.997243268
p_ni: 0.002756715
p_wrong: 1.7e-8
Data Source: BioPlex
MYCBP2
Tbio
Family: Enzyme
Novelty: 0.00413684
p_int: 0.99721176
p_ni: 0.00278824
Data Source: BioPlex
IL12RB1
Tbio
Novelty: 0.00398741
p_int: 0.996781174
p_ni: 0.000767372
p_wrong: 0.002451454
Score: 0.237
Data Source: BioPlex,STRINGDB
PER1
Tbio
Novelty: 0.01290576
p_int: 0.996316897
p_ni: 0.003683088
p_wrong: 1.6e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
MBD3
Tbio
Family: TF
Novelty: 0.04513502
p_int: 0.993835815
p_ni: 0.006164185
Score: 0.305
Data Source: BioPlex,STRINGDB
MTA1
Tbio
Family: TF
Novelty: 0.00464618
p_int: 0.989621491
p_ni: 0.010378509
Score: 0.181
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.989093902
p_ni: 0.010906098
Data Source: BioPlex
FAM91A1
Tbio
Novelty: 0.76982657
p_int: 0.9670944
p_ni: 0.031965838
p_wrong: 0.000939762
Score: 0.175
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  619.31

PubMed score by year
PubTator Score  231.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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