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Tbio
CD300LF
CMRF35-like molecule 1

Protein Summary
Description
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301573
  • ENSP00000301573
  • ENSG00000186074
  • ENST00000326165
  • ENSP00000327075
  • ENST00000343125
  • ENSP00000343751
  • ENST00000361254
  • ENSP00000355294
  • ENST00000462044
  • ENSP00000464223
  • ENST00000464910
  • ENSP00000464257
  • ENST00000469092
  • ENSP00000463743
  • ENST00000581500
  • ENSP00000464610

Symbol
  • CD300F
  • CLM1
  • IGSF13
  • IREM1
  • NKIR
  • CLM1
  • NKIR
  • CLM-1
  • IREM1
  • LMIR3
  • CD300f
  • IREM-1
  • IgSF13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
protein domain
0.58
cell type or tissue
0.57
cell line
0.56
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.26   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.26   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
3
4
98.5
monocyte count
2
2
2
89.1
myeloid white cell count
2
2
2
87.6
lymphocyte count
2
2
2
84.9
neutrophil count
2
1
2
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
98.5
monocyte count
2
89.1
myeloid white cell count
2
87.6
lymphocyte count
2
84.9
neutrophil count
2
72.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (80)
1 – 10 of 80
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
Score: 0.874
Data Source: STRINGDB
INPP5D
Tbio
Family: Enzyme
Novelty: 0.00630254
Score: 0.764
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.684
Data Source: STRINGDB
NCAM1
Tbio
Novelty: 0.00020994
Score: 0.683
Data Source: STRINGDB
FCER1G
Tbio
Novelty: 0.00783146
Score: 0.662
Data Source: STRINGDB
CD200R1
Tbio
Novelty: 0.00868438
Score: 0.646
Data Source: STRINGDB
CD300C
Tbio
Novelty: 0.00341957
Score: 0.617
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.613
Data Source: STRINGDB
HCST
Tbio
Novelty: 0.01604587
Score: 0.606
Data Source: STRINGDB
TREML1
Tbio
Novelty: 0.03513416
Score: 0.597
Data Source: STRINGDB
Publication Statistics
PubMed Score  87.26

PubMed score by year
PubTator Score  21.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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