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Tdark
MRPS21
28S ribosomal protein S21, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000581066
  • ENSP00000461930
  • ENSG00000266472
  • ENST00000614145
  • ENSP00000480129

Symbol
  • RPMS21
  • MDS016
  • RPMS21
  • MRP-S21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
disease perturbation
0.87
small molecule perturbation
0.79
interacting protein
0.73
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
69.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
69.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913542
66292
Dog
mitochondrial ribosomal protein S21
VGNC:43414
100855892
Horse
mitochondrial ribosomal protein S21
VGNC:20359
100058935
Cow
mitochondrial ribosomal protein S21
VGNC:31661
614343
Opossum
mitochondrial ribosomal protein S21
100014420
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
mitochondrial ribosomal protein S21
Horse
mitochondrial ribosomal protein S21
Cow
mitochondrial ribosomal protein S21
Opossum
mitochondrial ribosomal protein S21
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (131)
1 – 10 of 131
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.999434441
p_ni: 0.000565559
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.998404393
p_ni: 0.001595607
Score: 0.983
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.997462862
p_ni: 0.002537138
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.995601613
p_ni: 0.004398387
Score: 0.977
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.994275144
p_ni: 0.005724856
Score: 0.979
Data Source: BioPlex,STRINGDB
MRPS15
Tdark
Novelty: 0.37070563
p_int: 0.992667313
p_ni: 0.007332687
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.989656948
p_ni: 0.010343052
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.983628761
p_ni: 0.016371239
Score: 0.993
Data Source: BioPlex,STRINGDB
TRMT10B
Tdark
Family: Enzyme
Novelty: 0.61950381
p_int: 0.979980872
p_ni: 0.020019128
Score: 0.818
Data Source: BioPlex,STRINGDB
MRPS31
Tdark
Novelty: 0.28807342
p_int: 0.951627401
p_ni: 0.048372599
Score: 0.983
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.73

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer