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Tbio
SCIMP
SLP adapter and CSK-interacting membrane protein

Protein Summary
Description
Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399600
  • ENSP00000382509
  • ENSG00000161929
  • ENST00000571800
  • ENSP00000459605
  • ENST00000574081
  • ENSP00000461269

Symbol
  • C17orf87
  • UNQ5783
  • C17orf87
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
cell type or tissue
0.62
tissue
0.55
disease
0.44
transcription factor
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.2
Gene Ontology Terms (7)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (30)
1 – 10 of 30
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.998102394
p_ni: 0.001897606
Data Source: BioPlex
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.926583351
p_ni: 0.072413701
p_wrong: 0.001002948
Data Source: BioPlex
PRR7
Tbio
Novelty: 0.08132975
Score: 0.539
Data Source: STRINGDB
SPPL2A
Tbio
Family: Enzyme
Novelty: 0.02899909
Score: 0.53
Data Source: STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.516
Data Source: STRINGDB
ECHDC3
Tdark
Family: Enzyme
Novelty: 0.28181422
Score: 0.515
Data Source: STRINGDB
FAM217A
Tdark
Novelty: 52
Score: 0.511
Data Source: STRINGDB
GAPT
Tbio
Novelty: 0.05585518
Score: 0.498
Data Source: STRINGDB
LAT2
Tbio
Novelty: 0.01475258
Score: 0.497
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.494
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.04

PubMed score by year
PubTator Score  0.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer