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Tbio
CLUAP1
Clusterin-associated protein 1

Protein Summary
Description
Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000572600
  • ENSP00000460889
  • ENSG00000103351
  • ENST00000576634
  • ENSP00000460850

Symbol
  • KIAA0643
  • FAP22
  • IFT38
  • CFAP22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
transcription factor
0.67
transcription factor binding site profile
0.67
microRNA
0.65
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
67.7
self reported educational attainment
1
1
1
60
forced expiratory volume
1
1
1
53.5
cerebrospinal fluid biomarker measurement
1
1
1
33.7
alpha synuclein measurement
1
1
1
33.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
67.7
self reported educational attainment
1
60
forced expiratory volume
1
53.5
cerebrospinal fluid biomarker measurement
1
33.7
alpha synuclein measurement
1
33.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
clusterin associated protein 1
VGNC:5739
467890
Macaque
clusterin associated protein 1
703676
Mouse
MGI:1924029
76779
Rat
RGD:1359189
363544
Dog
clusterin associated protein 1
VGNC:39370
479868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
clusterin associated protein 1
Macaque
clusterin associated protein 1
Mouse
Rat
Dog
clusterin associated protein 1
Pathways (5)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Gene Ontology Terms (7)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (80)
1 – 10 of 80
TTC30A
Tdark
Novelty: 1.41742212
p_int: 0.999999977
p_ni: 2.2e-8
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
IFT22
Tbio
Family: Enzyme
Novelty: 0.18342877
p_int: 0.999999953
p_ni: 4.7e-8
Score: 0.976
Data Source: BioPlex,STRINGDB
IFT27
Tbio
Family: Enzyme
Novelty: 0.05592902
p_int: 0.999999918
p_ni: 6.4e-8
p_wrong: 1.8e-8
Score: 0.962
Data Source: BioPlex,STRINGDB
TTC30B
Tbio
Novelty: 0.10944566
p_int: 0.999999802
p_ni: 1.97e-7
Score: 0.992
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.999999566
p_ni: 4.33e-7
p_wrong: 1e-9
Data Source: BioPlex
CRACR2A
Tchem
Novelty: 0.11259702
p_int: 0.999824181
p_ni: 0.000175819
Score: 0.46
Data Source: BioPlex,STRINGDB
IFT57
Tbio
Novelty: 0.03373199
p_int: 0.999699105
p_ni: 8e-8
p_wrong: 0.000300815
Score: 0.996
Data Source: BioPlex,STRINGDB
TFPI2
Tbio
Novelty: 0.00475383
p_int: 0.997560765
p_ni: 0.002424248
p_wrong: 0.000014987
Data Source: BioPlex
TTC26
Tbio
Novelty: 0.10088384
Score: 0.986
Data Source: STRINGDB
IFT88
Tbio
Novelty: 0.00727114
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.80

PubMed score by year
PubTator Score  5.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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