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Tbio
SPON1
Spondin-1

Protein Summary
Description
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000576479
  • ENSP00000460236
  • ENSG00000262655

Symbol
  • KIAA0762
  • VSGP
  • f-spondin
  • VSGP/F-spondin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
kinase perturbation
0.71
small molecule perturbation
0.71
phenotype
0.7
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.16   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.16   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
9
12
99.7
spondin-1 measurement
1
2
2
86.9
blood protein measurement
1
1
1
82.5
body height
1
1
1
66.7
brain connectivity measurement
1
1
1
56.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
12
99.7
spondin-1 measurement
2
86.9
blood protein measurement
1
82.5
body height
1
66.7
brain connectivity measurement
1
56.3
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
DPY19L3
Tbio
Family: Enzyme
Novelty: 0.35244121
p_int: 0.999999443
p_ni: 5.57e-7
Data Source: BioPlex
C5orf22
Tdark
Novelty: 1.29325352
p_int: 0.999989044
p_ni: 0.000010757
p_wrong: 2e-7
Data Source: BioPlex
SULF2
Tbio
Family: Enzyme
Novelty: 0.01536228
p_int: 0.999450809
p_ni: 0.00054919
p_wrong: 1e-9
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.99760595
p_ni: 0.000222411
p_wrong: 0.002171638
Data Source: BioPlex
MKLN1
Tbio
Novelty: 0.05014385
p_int: 0.99603597
p_ni: 0.00396403
Data Source: BioPlex
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.994446041
p_ni: 0.005526936
p_wrong: 0.000027023
Data Source: BioPlex
WDR26
Tbio
Novelty: 0.04140166
p_int: 0.993255618
p_ni: 0.006744383
Data Source: BioPlex
MAEA
Tbio
Novelty: 0.00833813
p_int: 0.990469242
p_ni: 0.009530758
Data Source: BioPlex
RMND5A
Tbio
Novelty: 0.01820349
p_int: 0.987012069
p_ni: 0.012987931
Data Source: BioPlex
GID8
Tbio
Novelty: 0.21243963
p_int: 0.981752038
p_ni: 0.018247962
Data Source: BioPlex
Publication Statistics
PubMed Score  89.16

PubMed score by year
PubTator Score  32.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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