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Tchem
MMP12
Macrophage metalloelastase

Protein Summary
Description
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chrom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000571244
  • ENSP00000458585
  • ENSG00000262406

Symbol
  • HME
  • ME
  • HME
  • MME
  • MMP-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
biological term
0.87
disease
0.86
drug
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.93   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 568   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.93   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 568   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 386
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
86.6
emphysema pattern measurement
1
2
3
57.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
86.6
emphysema pattern measurement
3
57.4
Protein Data Bank (81)
1 – 5 of 81
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Collagen degradation (R-HSA-1442490)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Gene Ontology Terms (29)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (88)
1 – 10 of 88
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.959
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.952
Data Source: STRINGDB
ACAN
Tbio
Novelty: 0.00033695
Score: 0.94
Data Source: STRINGDB
COL18A1
Tbio
Novelty: 0.00074602
Score: 0.929
Data Source: STRINGDB
NID1
Tbio
Novelty: 0.00169075
Score: 0.928
Data Source: Reactome,STRINGDB
COL12A1
Tbio
Novelty: 0.0239421
Score: 0.925
Data Source: STRINGDB
LAMA3
Tbio
Novelty: 0.00733792
Score: 0.923
Data Source: STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.00159541
Score: 0.915
Data Source: STRINGDB
LAMB3
Tbio
Novelty: 0.00717673
Score: 0.915
Data Source: STRINGDB
A2M
Tbio
Novelty: 0.00070446
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  651.93

PubMed score by year
PubTator Score  349.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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