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Tbio
ZNF423
Zinc finger protein 423

Protein Summary
Description
Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262383
  • ENSP00000262383
  • ENSG00000102935
  • ENST00000561648
  • ENSP00000455426
  • ENST00000562520
  • ENSP00000457664
  • ENST00000562871
  • ENSP00000457928
  • ENST00000563137
  • ENSP00000455588

Symbol
  • KIAA0760
  • NPHP14
  • OAZ
  • OAZ
  • Roaz
  • hOAZ
  • Ebfaz
  • JBTS19
  • NPHP14
  • ZFP423
  • Zfp104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
trait
0.86
PubMedID
0.83
transcription factor perturbation
0.74
biological process
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.85   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.85   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
96.5
smoking status measurement
2
4
4
94.3
mathematical ability
3
2
3
84.7
heel bone mineral density
2
1
2
78.7
smoking initiation
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
96.5
smoking status measurement
4
94.3
mathematical ability
3
84.7
heel bone mineral density
2
78.7
smoking initiation
1
70.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 423
VGNC:5965
465158
Macaque
zinc finger protein 423
693808
Mouse
MGI:1891217
94187
Dog
zinc finger protein 423
VGNC:48723
487291
Horse
zinc finger protein 423
VGNC:25321
100058325
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 423
Macaque
zinc finger protein 423
Mouse
Dog
zinc finger protein 423
Horse
zinc finger protein 423
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q2M1K9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) )
Name
Explore in Pharos
Explore in Source
BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) )
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (78)
1 – 10 of 78
ZG16B
Tbio
Novelty: 0.08792924
p_int: 0.999999864
p_ni: 1.35e-7
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999999832
p_ni: 1.64e-7
p_wrong: 5e-9
Score: 0.65
Data Source: BioPlex,STRINGDB
MTA1
Tbio
Family: TF
Novelty: 0.00464618
p_int: 0.99999981
p_ni: 1.9e-7
Score: 0.828
Data Source: BioPlex,STRINGDB
ZNF219
Tbio
Family: TF
Novelty: 0.17515242
p_int: 0.9999981
p_ni: 0.000001764
p_wrong: 1.36e-7
Score: 0.83
Data Source: BioPlex,STRINGDB
MBD3L1
Tbio
Novelty: 0.11297566
p_int: 0.99988096
p_ni: 0.000089397
p_wrong: 0.000029643
Score: 0.844
Data Source: BioPlex,STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.91
Data Source: STRINGDB
EBF1
Tbio
Family: TF
Novelty: 0.00445405
Score: 0.89
Data Source: STRINGDB
EBF2
Tbio
Family: TF
Novelty: 0.00921566
Score: 0.717
Data Source: STRINGDB
FBXL7
Tbio
Novelty: 0.10670779
Score: 0.717
Data Source: STRINGDB
EZH1
Tchem
Family: Epigenetic
Novelty: 0.02636757
Score: 0.709
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.85

PubMed score by year
PubTator Score  29.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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