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Tbio
TRAF3
TNF receptor-associated factor 3

Protein Classes
Protein Summary
Description
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392745
  • ENSP00000376500
  • ENSG00000131323
  • ENST00000539721
  • ENSP00000445998
  • ENST00000560371
  • ENSP00000454207

Symbol
  • CAP1
  • CRAF1
  • CAP1
  • LAP1
  • CAP-1
  • CRAF1
  • IIAE5
  • CD40bp
  • RNF118
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.98
hub protein
0.85
molecular function
0.84
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.62   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 495   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.62   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
3
6
98.4
lymphocyte count
3
3
3
88.6
2
2
0
1.1
79.8
lymphocyte percentage of leukocytes
2
2
2
66.7
1
1
1
65.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
98.4
lymphocyte count
3
88.6
0
1.1
79.8
lymphocyte percentage of leukocytes
2
66.7
1
65.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 3
VGNC:12392
453178
Macaque
TNF receptor associated factor 3
693961
Mouse
MGI:108041
22031
Rat
RGD:1304633
362788
Dog
TNF receptor associated factor 3
VGNC:47764
490867
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 3
Macaque
TNF receptor associated factor 3
Mouse
Rat
Dog
TNF receptor associated factor 3
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13114-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (62)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Deubiquitination
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Deubiquitination
Disease
Gene Ontology Terms (27)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (275)
1 – 10 of 275
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999999914
p_ni: 8.5e-8
p_wrong: 1e-9
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999999886
p_ni: 1.13e-7
Score: 0.379
Data Source: BioPlex,STRINGDB
SNAP29
Tbio
Novelty: 0.02009206
p_int: 0.999999184
p_ni: 8.16e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
ECH1
Tbio
Family: Enzyme
Novelty: 0.02471875
p_int: 0.999998441
p_ni: 0.000001559
Score: 0.244
Data Source: BioPlex,STRINGDB
TNFRSF8
Tclin
Novelty: 0.00030231
p_int: 0.99998856
p_ni: 0.00001144
Score: 0.637
Data Source: BioPlex,STRINGDB
TSKS
Tbio
Family: Enzyme
Novelty: 0.0886446
p_int: 0.999976559
p_ni: 0.000023438
p_wrong: 2e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
EDA2R
Tbio
Novelty: 0.03463669
p_int: 0.999974501
p_ni: 0.000025498
p_wrong: 1e-9
Score: 0.619
Data Source: BioPlex,STRINGDB
MAP3K14
Tchem
Family: Kinase
Novelty: 0.0350173
p_int: 0.999910945
p_ni: 0.000089004
p_wrong: 5.1e-8
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
SHPK
Tbio
Family: Kinase
Novelty: 0.16166855
p_int: 0.999736063
p_ni: 0.000263869
p_wrong: 6.8e-8
Score: 0.243
Data Source: BioPlex,STRINGDB
CD40
Tchem
Novelty: 0.0002836
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  435.62

PubMed score by year
PubTator Score  270.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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