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Tbio
SHISA9
Protein shisa-9

Protein Summary
Description
Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423335
  • ENSP00000395245
  • ENSG00000237515
  • ENST00000558583
  • ENSP00000454014

Symbol
  • CKAMP44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.98
phenotype
0.77
trait
0.75
disease
0.73
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
3
2
0
1
98.6
intelligence
1
2
0
5.8
82.2
neuroticism measurement
2
3
1
5.7
76.5
1
1
0
1
74.5
mathematical ability
2
2
2
67.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
98.6
intelligence
0
5.8
82.2
neuroticism measurement
1
5.7
76.5
0
1
74.5
mathematical ability
2
67.5
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (78)
1 – 10 of 78
CNIH2
Tbio
Novelty: 0.08676822
Score: 0.922
Data Source: STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
Score: 0.921
Data Source: STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.9
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00141257
Score: 0.867
Data Source: STRINGDB
CNIH3
Tdark
Novelty: 0.22096987
Score: 0.856
Data Source: STRINGDB
GRIA3
Tclin
Family: IC
Novelty: 0.00584546
Score: 0.827
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.8
Data Source: STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.79
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
Score: 0.79
Data Source: STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00035058
Score: 0.782
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.40

PubMed score by year
PubTator Score  2.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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