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Tbio
B2M
Beta-2-microglobulin

Protein Summary
Description
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000558401
  • ENSP00000452780
  • ENSG00000166710
  • ENST00000559916
  • ENSP00000453350
  • ENST00000561424
  • ENSP00000453191
  • ENST00000617605
  • ENSP00000481426
  • ENSG00000273686
  • ENST00000631573
  • ENSP00000488548
  • ENST00000631728
  • ENSP00000488321
  • ENST00000648006
  • ENSP00000497910

Symbol
  • IMD43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease perturbation
1
virus perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8221.43   (req: < 5)
Gene RIFs: 262   (req: <= 3)
Antibodies: 2183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8221.43   (req: >= 5)
Gene RIFs: 262   (req: > 3)
Antibodies: 2183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (734)
1 – 5 of 734
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amyloid fiber formation
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amyloid fiber formation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (59)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (504)
1 – 10 of 504
RGPD2
Tdark
Novelty: 0.05926762
p_int: 0.999999975
p_ni: 6e-9
p_wrong: 1.9e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
FCGRT
Tchem
Novelty: 0.0014463
p_int: 0.999999467
p_ni: 5.33e-7
Score: 0.963
Data Source: BioPlex,STRINGDB
RGPD5
Tdark
Novelty: 0.26241703
p_int: 0.99999784
p_ni: 0.00000216
Data Source: BioPlex
DLGAP5
Tbio
Novelty: 0.02195205
p_int: 0.99998432
p_ni: 0.00001566
p_wrong: 2e-8
Score: 0.524
Data Source: BioPlex,STRINGDB
TPST1
Tbio
Family: Enzyme
Novelty: 0.04723781
p_int: 0.999839163
p_ni: 0.000122084
p_wrong: 0.000038753
Score: 0.19
Data Source: BioPlex,STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00648364
p_int: 0.999805914
p_ni: 0.000194086
Score: 0.815
Data Source: BioPlex,STRINGDB
RANGAP1
Tbio
Family: Enzyme
Novelty: 0.01406078
p_int: 0.99862759
p_ni: 0.00137241
Score: 0.827
Data Source: BioPlex,STRINGDB
CD1E
Tbio
Novelty: 0.00231902
p_int: 0.990978394
p_ni: 0.009021497
p_wrong: 1.09e-7
Score: 0.795
Data Source: BioPlex,STRINGDB
KPNA4
Tbio
Novelty: 0.02255219
p_int: 0.981971745
p_ni: 0.018028255
Score: 0.183
Data Source: BioPlex,STRINGDB
CDCA2
Tbio
Novelty: 0.06301908
p_int: 0.976364702
p_ni: 0.021044365
p_wrong: 0.002590932
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8221.43

PubMed score by year
PubTator Score  6607.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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