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Tbio
ITGA7
Integrin alpha-7

Protein Summary
Description
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257879
  • ENSP00000257879
  • ENSG00000135424
  • ENST00000452168
  • ENSP00000393844
  • ENST00000553804
  • ENSP00000452120
  • ENST00000555728
  • ENSP00000452387
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
cellular component
0.79
gene perturbation
0.74
protein domain
0.73
cell type or tissue
0.72


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.93   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.93   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 7
VGNC:5436
451967
Mouse
MGI:102700
16404
Rat
RGD:71022
81008
Dog
integrin subunit alpha 7
VGNC:42129
481097
Horse
integrin subunit alpha 7
VGNC:19168
100058756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 7
Mouse
Rat
Dog
integrin subunit alpha 7
Horse
integrin subunit alpha 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13683-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (43)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Reactome
Laminin interactions
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Integrin cell surface interactions
Laminin interactions
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (169)
1 – 10 of 169
TSPAN11
Tdark
Novelty: 0.37247094
p_int: 0.999800575
p_ni: 0.000199425
Score: 0.282
Data Source: BioPlex,STRINGDB
SUSD4
Tbio
Novelty: 0.22201938
p_int: 0.999257032
p_ni: 0.000742968
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.999081442
p_ni: 0.000918558
Data Source: BioPlex
EDDM3B
Tdark
Novelty: 0.12874735
p_int: 0.995787159
p_ni: 0.004212839
p_wrong: 2e-9
Data Source: BioPlex
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.994101359
p_ni: 0.005898641
Data Source: BioPlex
PTCH1
Tbio
Novelty: 0.00077635
p_int: 0.993660827
p_ni: 0.006339171
p_wrong: 2e-9
Data Source: BioPlex
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.993226156
p_ni: 0.006773844
p_wrong: 1e-9
Data Source: BioPlex
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.977412278
p_ni: 0.022587554
p_wrong: 1.67e-7
Data Source: BioPlex
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.970248928
p_ni: 0.029751055
p_wrong: 1.7e-8
Data Source: BioPlex
RLN1
Tbio
Novelty: 0.03992636
p_int: 0.958284858
p_ni: 0.041713011
p_wrong: 0.000002131
Data Source: BioPlex
Publication Statistics
PubMed Score  80.93

PubMed score by year
PubTator Score  33.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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