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Tbio
XRCC3
DNA repair protein XRCC3

Protein Summary
Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. This gene encodes a member of the RecA/Rad51-related protein family that p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352127
  • ENSP00000343392
  • ENSG00000126215
  • ENST00000553264
  • ENSP00000451974
  • ENST00000554913
  • ENSP00000451362
  • ENST00000555055
  • ENSP00000452598

Symbol
  • CMM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease
0.88
phenotype
0.81
cell type or tissue
0.67
small molecule perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.39   (req: < 5)
Gene RIFs: 261   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.39   (req: >= 5)
Gene RIFs: 261   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
23.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
23.4
Pathways (117)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homologous DNA Pairing and Strand Exchange
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homologous DNA Pairing and Strand Exchange
Gene Ontology Terms (26)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (222)
1 – 10 of 222
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.967995202
p_ni: 0.032002013
p_wrong: 0.000002785
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.967392463
p_ni: 0.032607537
Data Source: BioPlex
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.947541182
p_ni: 0.052458818
Data Source: BioPlex
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.925062183
p_ni: 0.074920591
p_wrong: 0.000017226
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.02936208
p_int: 0.888220416
p_ni: 0.111779583
p_wrong: 1e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.885371404
p_ni: 0.114628595
p_wrong: 1e-9
Data Source: BioPlex
C5AR2
Tbio
Family: GPCR
Novelty: 0.01193736
p_int: 0.869553439
p_ni: 0.130446554
p_wrong: 7e-9
Data Source: BioPlex
SPCS3
Tbio
Family: Enzyme
Novelty: 0.13677259
p_int: 0.865378876
p_ni: 0.134618363
p_wrong: 0.000002761
Data Source: BioPlex
IL5RA
Tclin
Novelty: 0.01418963
p_int: 0.855925143
p_ni: 0.144065178
p_wrong: 0.000009678
Data Source: BioPlex
INSYN2
Tdark
Novelty: 2.55244594
p_int: 0.85098396
p_ni: 0.149000233
p_wrong: 0.000015807
Data Source: BioPlex
Publication Statistics
PubMed Score  363.39

PubMed score by year
PubTator Score  283.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer