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Tbio
NUMB
Protein numb homolog

Protein Classes
Protein Summary
Description
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355058
  • ENSP00000347169
  • ENSG00000133961
  • ENST00000356296
  • ENSP00000348644
  • ENST00000359560
  • ENSP00000352563
  • ENST00000535282
  • ENSP00000441258
  • ENST00000544991
  • ENSP00000446001
  • ENST00000554521
  • ENSP00000450817
  • ENST00000554546
  • ENSP00000452416
  • ENST00000555238
  • ENSP00000451300
  • ENST00000555394
  • ENSP00000451625
  • ENST00000555738
  • ENSP00000452069
  • ENST00000557597
  • ENSP00000451117
  • ENST00000559312
  • ENSP00000452888
  • ENST00000560335
  • ENSP00000453209

Symbol
  • C14orf41
  • S171
  • C14orf41
  • c14_5527
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
transcription factor perturbation
0.84
cellular component
0.78
disease perturbation
0.74
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.8   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 743   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.8   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 743   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
33.1
multisite chronic pain
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
33.1
multisite chronic pain
1
16.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NUMB, endocytic adaptor protein
453014
Macaque
NUMB, endocytic adaptor protein
696528
Mouse
MGI:107423
18222
Rat
RGD:620107
29419
Dog
NUMB, endocytic adaptor protein
VGNC:49933
480381
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NUMB, endocytic adaptor protein
Macaque
NUMB, endocytic adaptor protein
Mouse
Rat
Dog
NUMB, endocytic adaptor protein
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (40)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Axon guidance
Reactome
Degradation of GLI1 by the proteasome
Reactome
Developmental Biology
Reactome
Hedgehog 'off' state
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Axon guidance
Degradation of GLI1 by the proteasome
Developmental Biology
Hedgehog 'off' state
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (212)
1 – 10 of 212
NUMBL
Tbio
Novelty: 0.01383607
p_int: 0.999999746
p_ni: 1e-9
p_wrong: 2.53e-7
Score: 0.81
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.99991049
p_ni: 0.00008951
Score: 0.451
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.999811838
p_ni: 0.000151066
p_wrong: 0.000037095
Score: 0.303
Data Source: BioPlex,STRINGDB
UNC5CL
Tbio
Novelty: 0.11511991
p_int: 0.999019936
p_ni: 0.000980037
p_wrong: 2.7e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
KLHL21
Tbio
Novelty: 0.20694121
p_int: 0.998302901
p_ni: 0.001472891
p_wrong: 0.000224209
Data Source: BioPlex
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.994630319
p_ni: 0.004705278
p_wrong: 0.000664403
Score: 0.219
Data Source: BioPlex,STRINGDB
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.99172125
p_ni: 0.006443876
p_wrong: 0.001834875
Score: 0.165
Data Source: BioPlex,STRINGDB
COL10A1
Tbio
Novelty: 0.00521991
p_int: 0.935987305
p_ni: 0.064002708
p_wrong: 0.000009988
Score: 0.214
Data Source: BioPlex,STRINGDB
PKD2
Tchem
Family: IC
Novelty: 0.00305329
p_int: 0.932465679
p_ni: 0.067532056
p_wrong: 0.000002264
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.910635664
p_ni: 0.089364337
Data Source: BioPlex
Publication Statistics
PubMed Score  504.80

PubMed score by year
PubTator Score  341.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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