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Tbio
SERPINA3
Alpha-1-antichymotrypsin

Protein Summary
Description
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393078
  • ENSP00000376793
  • ENSG00000196136
  • ENST00000393080
  • ENSP00000376795
  • ENST00000467132
  • ENSP00000450540
  • ENST00000556968
  • ENSP00000452476

Symbol
  • AACT
  • ACT
  • AACT
  • GIG24
  • GIG25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
disease
0.83
disease perturbation
0.83
small molecule perturbation
0.77
transcription factor perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1300.47   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1300.47   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01011-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Platelet activation, signaling and aggregation
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (89)
1 – 10 of 89
TEFM
Tbio
Novelty: 0.10836617
p_int: 0.999977405
p_ni: 0.000022595
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.999318936
p_ni: 0.00068104
p_wrong: 2.5e-8
Data Source: BioPlex
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999299287
p_ni: 0.000692096
p_wrong: 0.000008617
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999211763
p_ni: 0.000788237
Data Source: BioPlex
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
p_int: 0.998134994
p_ni: 0.001864345
p_wrong: 6.61e-7
Score: 0.286
Data Source: BioPlex,STRINGDB
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.996834412
p_ni: 0.003141785
p_wrong: 0.000023803
Data Source: BioPlex
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.993415838
p_ni: 0.006584148
p_wrong: 1.4e-8
Data Source: BioPlex
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.987226355
p_ni: 0.012772546
p_wrong: 0.000001098
Data Source: BioPlex
DDX60
Tbio
Family: Enzyme
Novelty: 0.09487565
p_int: 0.978035902
p_ni: 0.02194289
p_wrong: 0.000021208
Data Source: BioPlex
C16orf70
Tdark
Novelty: 2.12573065
p_int: 0.959326513
p_ni: 0.040673487
Data Source: BioPlex
Publication Statistics
PubMed Score  1300.47

PubMed score by year
PubTator Score  749.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer