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Tbio
PPFIA2
Liprin-alpha-2

Protein Summary
Description
Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mamma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333447
  • ENSP00000327416
  • ENSG00000139220
  • ENST00000407050
  • ENSP00000385093
  • ENST00000443686
  • ENSP00000388373
  • ENST00000541017
  • ENSP00000445532
  • ENST00000541570
  • ENSP00000438337
  • ENST00000548586
  • ENSP00000449338
  • ENST00000549325
  • ENSP00000450298
  • ENST00000549396
  • ENSP00000450337
  • ENST00000552948
  • ENSP00000447868
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.7
histone modification site profile
0.68
tissue sample
0.61
microRNA
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
76.1
self reported educational attainment
1
1
1
37.9
cognitive function measurement
1
1
1
15.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
76.1
self reported educational attainment
1
37.9
cognitive function measurement
1
15.9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (101)
1 – 10 of 101
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999930881
p_ni: 3e-9
p_wrong: 0.000069116
Data Source: BioPlex
CASK
Tchem
Family: Kinase
Novelty: 0.00856437
Score: 0.987
Data Source: STRINGDB
PTPRF
Tchem
Family: Enzyme
Novelty: 0.01017327
Score: 0.974
Data Source: Reactome,STRINGDB
RIMS1
Tbio
Novelty: 0.01126545
Score: 0.965
Data Source: Reactome,STRINGDB
LIN7A
Tbio
Novelty: 0.0202389
Score: 0.96
Data Source: STRINGDB
PTPRD
Tbio
Family: Enzyme
Novelty: 0.01059407
Score: 0.956
Data Source: Reactome,STRINGDB
PTPRS
Tchem
Family: Enzyme
Novelty: 0.00587115
Score: 0.948
Data Source: Reactome,STRINGDB
LIN7B
Tbio
Novelty: 0.12689192
Score: 0.947
Data Source: STRINGDB
SNAP25
Tclin
Novelty: 0.00148905
Score: 0.938
Data Source: STRINGDB
APBA1
Tbio
Novelty: 0.01126648
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.76

PubMed score by year
PubTator Score  3.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer