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Tbio
RNASEK
Ribonuclease kappa

Protein Summary
Description
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000548577
  • ENSP00000449500
  • ENSG00000219200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
virus perturbation
0.83
small molecule perturbation
0.81
transcription factor perturbation
0.8
kinase perturbation
0.71


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease K
VGNC:9563
100610992
Rat
RGD:1305687
287453
Dog
ribonuclease K
VGNC:54351
607349
Horse
ribonuclease K
VGNC:22419
100147426
Cow
ribonuclease K
VGNC:34002
512886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease K
Rat
Dog
ribonuclease K
Horse
ribonuclease K
Cow
ribonuclease K
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6P5S7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (8)
1 – 8 of 8
TBC1D20
Tbio
Novelty: 0.08651866
Score: 0.599
Data Source: STRINGDB
LZTS3
Tbio
Novelty: 0.16172039
Score: 0.537
Data Source: STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
Score: 0.531
Data Source: STRINGDB
PPP1R8
Tbio
Family: Enzyme
Novelty: 0.00138054
Score: 0.528
Data Source: STRINGDB
TCEAL2
Tdark
Novelty: 0.2679989
Score: 0.512
Data Source: STRINGDB
TWIST2
Tbio
Family: TF
Novelty: 0.00748285
Score: 0.472
Data Source: STRINGDB
TMEM185A
Tdark
Novelty: 0.0262898
Score: 0.43
Data Source: STRINGDB
SLC16A11
Tbio
Family: Transporter
Novelty: 0.07860306
Score: 0.42
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.18

PubMed score by year
PubTator Score  11.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer