You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KRT8
Keratin, type II cytoskeletal 8

Protein Summary
Description
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293308
  • ENSP00000293308
  • ENSG00000170421
  • ENST00000546897
  • ENSP00000447402
  • ENST00000552150
  • ENSP00000449404
  • ENST00000552551
  • ENSP00000447566

Symbol
  • CYK8
  • K8
  • KO
  • CK8
  • CK-8
  • CYK8
  • K2C8
  • CARD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.99
transcription factor perturbation
0.99
interacting protein
0.98
disease perturbation
0.97
hub protein
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 966.12   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 3208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 966.12   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 3208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
3
2
0
1.2
95.5
mean reticulocyte volume
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.2
95.5
mean reticulocyte volume
1
10.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
keratin 8
700449
Mouse
MGI:96705
16691
Rat
RGD:2984
25626
Dog
keratin 8
486513
Pig
keratin 8
100152077
Species
Name
OMA
EggNOG
Inparanoid
Macaque
keratin 8
Mouse
Rat
Dog
keratin 8
Pig
keratin 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P05787-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Protein-Protein Interactions (182)
1 – 10 of 182
KRT18
Tbio
Novelty: 0.00069055
Score: 0.997
Data Source: STRINGDB
KRT19
Tbio
Novelty: 0.00043162
Score: 0.97
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.955
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.00278761
Score: 0.953
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.00088743
Score: 0.942
Data Source: STRINGDB
KRT13
Tbio
Novelty: 0.00468754
Score: 0.941
Data Source: STRINGDB
KRT20
Tbio
Novelty: 0.00132004
Score: 0.938
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.936
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00503235
Score: 0.935
Data Source: STRINGDB
KRT10
Tbio
Novelty: 0.00166073
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  966.12

PubMed score by year
PubTator Score  710.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: