You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DNM1L
Dynamin-1-like protein

Protein Summary
Description
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266481
  • ENSP00000266481
  • ENSG00000087470
  • ENST00000381000
  • ENSP00000370388
  • ENST00000414834
  • ENSP00000404160
  • ENST00000452533
  • ENSP00000415131
  • ENST00000547312
  • ENSP00000448610
  • ENST00000549701
  • ENSP00000450399
  • ENST00000553257
  • ENSP00000449089

Symbol
  • DLP1
  • DRP1
  • DLP1
  • DRP1
  • DVLP
  • EMPF
  • OPA5
  • EMPF1
  • DYMPLE
  • HDYNIV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.98
protein domain
0.97
transcription factor perturbation
0.97
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 793.55   (req: < 5)
Gene RIFs: 162   (req: <= 3)
Antibodies: 580   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 793.55   (req: >= 5)
Gene RIFs: 162   (req: > 3)
Antibodies: 580   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
53
platelet count
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
53
platelet count
1
9.5
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic execution phase
Programmed Cell Death
Gene Ontology Terms (71)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred by Curator (IC)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (214)
1 – 10 of 214
DPPA5
Tbio
Novelty: 0.09402178
p_int: 0.999999953
p_ni: 4.6e-8
p_wrong: 2e-9
Data Source: BioPlex
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.999997296
p_ni: 0.000002704
Score: 0.159
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.99981869
p_ni: 0.000181244
p_wrong: 6.7e-8
Data Source: BioPlex
JTB
Tbio
Novelty: 0.06646216
p_int: 0.997861319
p_ni: 0.00213787
p_wrong: 8.12e-7
Data Source: BioPlex
CA14
Tclin
Family: Enzyme
Novelty: 0.00864764
p_int: 0.996576656
p_ni: 0.003226159
p_wrong: 0.000197185
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.995801917
p_ni: 0.004198082
p_wrong: 1e-9
Data Source: BioPlex
FGL1
Tbio
Novelty: 0.02650803
p_int: 0.99537157
p_ni: 0.004628384
p_wrong: 4.6e-8
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.985328318
p_ni: 0.014522653
p_wrong: 0.000149029
Score: 0.194
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.979649932
p_ni: 0.020349974
p_wrong: 9.4e-8
Score: 0.215
Data Source: BioPlex,STRINGDB
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.965333197
p_ni: 0.034666655
p_wrong: 1.48e-7
Score: 0.303
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  793.55

PubMed score by year
PubTator Score  320.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: