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Tchem
CPM
Carboxypeptidase M

Protein Summary
Description
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338356
  • ENSP00000339157
  • ENSG00000135678
  • ENST00000546373
  • ENSP00000447255
  • ENST00000551568
  • ENSP00000448517
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.91
kinase perturbation
0.71
small molecule perturbation
0.69
cell type or tissue
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.84   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.84   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to silica exposure
1
1
0
2.2
3.7
pneumoconiosis
1
1
0
2.2
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to silica exposure
0
2.2
3.7
pneumoconiosis
0
2.2
3.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase M
VGNC:12901
452067
Macaque
carboxypeptidase M
718315
Mouse
MGI:1917824
70574
Rat
RGD:1310532
314855
Dog
carboxypeptidase M
VGNC:54521
100685525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase M
Macaque
carboxypeptidase M
Mouse
Rat
Dog
carboxypeptidase M
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14384-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (104)
1 – 10 of 104
ZSCAN12
Tdark
Family: TF
Novelty: 0.33578207
p_int: 0.999992867
p_ni: 0.000007116
p_wrong: 1.7e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
ULBP1
Tbio
Novelty: 0.01603533
p_int: 0.917711865
p_ni: 0.000296915
p_wrong: 0.08199122
Score: 0.345
Data Source: BioPlex,STRINGDB
FTH1
Tbio
Novelty: 0.000863
p_int: 0.900032619
p_ni: 0.000017229
p_wrong: 0.099950151
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.855753068
p_ni: 0.000021617
p_wrong: 0.144225315
Data Source: BioPlex
GTPBP3
Tbio
Family: Enzyme
Novelty: 0.08129502
p_int: 0.826491669
p_ni: 0.173508331
Score: 0.282
Data Source: BioPlex,STRINGDB
IZUMO1R
Tbio
Novelty: 0.02670576
Score: 0.918
Data Source: STRINGDB
XPNPEP2
Tchem
Family: Enzyme
Novelty: 0.01453123
Score: 0.912
Data Source: STRINGDB
THY1
Tbio
Novelty: 0.00032846
Score: 0.903
Data Source: STRINGDB
ULBP2
Tbio
Novelty: 0.01604318
Score: 0.903
Data Source: STRINGDB
LYPD6B
Tdark
Novelty: 0.1409054
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  181.84

PubMed score by year
PubTator Score  64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer