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Tbio
SLC8B1
Mitochondrial sodium/calcium exchanger protein

Protein Summary
Description
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000202831
  • ENSP00000202831
  • ENSG00000089060
  • ENST00000546737
  • ENSP00000450081
  • ENST00000552014
  • ENSP00000447091

Symbol
  • NCKX6
  • NCLX
  • SLC24A6
  • NCLX
  • NCKX6
  • SLC24A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
cellular component
0.75
histone modification site profile
0.72
kinase perturbation
0.71
small molecule perturbation
0.67


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.27   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.27   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member B1
VGNC:8549
452406
Mouse
MGI:2180781
170756
Rat
RGD:1565818
498185
Dog
solute carrier family 8 member B1
VGNC:46483
486280
Horse
solute carrier family 8 member B1
VGNC:23276
100056481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 8 member B1
Mouse
Rat
Dog
solute carrier family 8 member B1
Horse
solute carrier family 8 member B1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6J4K2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium/Calcium exchangers
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
SLC-mediated transmembrane transport
Sodium/Calcium exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (25)
1 – 10 of 25
MCU
Tbio
Family: IC
Novelty: 0.00114914
Score: 0.84
Data Source: STRINGDB
LETM1
Tbio
Novelty: 0.01542461
Score: 0.828
Data Source: STRINGDB
MICU1
Tbio
Novelty: 0.00984731
Score: 0.802
Data Source: STRINGDB
SLC8A3
Tchem
Family: Transporter
Novelty: 0.01041945
Score: 0.73
Data Source: STRINGDB
SLC8A2
Tbio
Family: Transporter
Novelty: 0.01423879
Score: 0.722
Data Source: STRINGDB
MICU2
Tbio
Novelty: 0.04146208
Score: 0.667
Data Source: STRINGDB
SLC8A1
Tchem
Family: Transporter
Novelty: 0.0023933
Score: 0.638
Data Source: STRINGDB
MCUR1
Tbio
Novelty: 0.06505266
Score: 0.627
Data Source: STRINGDB
PINK1
Tbio
Family: Kinase
Novelty: 0.00100973
Score: 0.61
Data Source: STRINGDB
MCUB
Tbio
Novelty: 0.0486243
Score: 0.605
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.27

PubMed score by year
PubTator Score  26.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer