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Tchem
BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

Protein Summary
Description
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000551812
  • ENSP00000446880
  • ENSG00000076108

Symbol
  • KIAA0314
  • TIP5
  • TIP5
  • WALp3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.92
biological process
0.81
disease perturbation
0.79
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1997.03   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1997.03   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (12)
1 – 10 of 12
CHEMBL3739699
chemical structure image
CHEMBL3415187
chemical structure image
CHEMBL3770277
chemical structure image
CHEMBL3770214
chemical structure image
CHEMBL3415185
chemical structure image
CHEMBL3415184
chemical structure image
CHEMBL3770199
chemical structure image
CHEMBL3771216
chemical structure image
CHEMBL3415182
chemical structure image
BAZ2-ICR
chemical structure image
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Epigenetic regulation of gene expression (R-HSA-212165)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (118)
1 – 10 of 118
SMARCA5
Tbio
Novelty: 0.00717086
Score: 0.984
Data Source: Reactome,STRINGDB
TTF1
Tbio
Family: TF
Novelty: 0.03427615
Score: 0.984
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00083441
Score: 0.959
Data Source: STRINGDB
DNMT3B
Tchem
Family: Epigenetic
Novelty: 0.00164012
Score: 0.948
Data Source: STRINGDB
DNMT1
Tclin
Family: Enzyme
Novelty: 0.0005455
Score: 0.944
Data Source: STRINGDB
ARID4B
Tbio
Family: TF; Epigenetic
Novelty: 0.05116399
Score: 0.939
Data Source: STRINGDB
H2AFZ
Tbio
Novelty: 0.00281312
Score: 0.936
Data Source: STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00121358
Score: 0.932
Data Source: STRINGDB
H2AFV
Tbio
Novelty: 0.06257527
Score: 0.931
Data Source: STRINGDB
H2AFX
Tbio
Novelty: 0.00052244
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  1997.03

PubMed score by year
PubTator Score  32.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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