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Tbio
GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

Protein Summary
Description
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000551765
  • ENSP00000446872
  • ENSG00000257218

Symbol
  • 15E1.2
  • 15E1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.84
kinase perturbation
0.81
cell type or tissue
0.79
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
49.4
mean reticulocyte volume
1
1
1
37.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
49.4
mean reticulocyte volume
1
37.4
Protein-Protein Interactions (26)
1 – 10 of 26
QRSL1
Tbio
Family: Enzyme
Novelty: 0.0076614
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
GATB
Tbio
Family: Enzyme
Novelty: 0.01269151
p_int: 0.99999998
p_ni: 2e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
HIBCH
Tbio
Family: Enzyme
Novelty: 0.02964018
p_int: 0.999768225
p_ni: 0.000231775
Score: 0.158
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.999466713
p_ni: 0.000533284
p_wrong: 2e-9
Data Source: BioPlex
CYP4V2
Tbio
Novelty: 0.00542449
p_int: 0.979963882
p_ni: 0.020004742
p_wrong: 0.000031375
Score: 0.19
Data Source: BioPlex,STRINGDB
PDPR
Tbio
Family: Enzyme
Novelty: 0.04223174
p_int: 0.961550317
p_ni: 0.038449683
Data Source: BioPlex
NARS2
Tbio
Family: Enzyme
Novelty: 0.01879317
p_int: 0.924009454
p_ni: 0.071072725
p_wrong: 0.004917821
Score: 0.912
Data Source: BioPlex,STRINGDB
D2HGDH
Tbio
Family: Enzyme
Novelty: 0.04618268
p_int: 0.910407246
p_ni: 0.085354315
p_wrong: 0.004238439
Score: 0.177
Data Source: BioPlex,STRINGDB
PUS1
Tbio
Family: Enzyme
Novelty: 0.01923618
p_int: 0.873652603
p_ni: 0.126336085
p_wrong: 0.000011312
Score: 0.313
Data Source: BioPlex,STRINGDB
POLG
Tchem
Family: Enzyme
Novelty: 0.00172189
p_int: 0.842328865
p_ni: 0.157670986
p_wrong: 1.49e-7
Score: 0.583
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.55

PubMed score by year
PubTator Score  58.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer