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Tbio
RAN
GTP-binding nuclear protein Ran

Protein Summary
Description
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
interacting protein
1
molecular function
1
kinase perturbation
0.99


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Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 538.81   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 555   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 538.81   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 555   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pemphigus foliaceus
1
1
0
3
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pemphigus foliaceus
0
3
10.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAN, member RAS oncogene family
VGNC:13367
452414
Macaque
RAN, member RAS oncogene family
709200
Mouse
MGI:1333112
19384
Rat
RGD:620367
84509
Dog
RAN, member RAS oncogene family
100499482
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAN, member RAS oncogene family
Macaque
RAN, member RAS oncogene family
Mouse
Rat
Dog
RAN, member RAS oncogene family
Protein Structure (67 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62826-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 67
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Export of Viral Ribonucleoproteins from Nucleus
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
HIV Infection
Name
Explore in Pharos
Explore in Source
Disease
Export of Viral Ribonucleoproteins from Nucleus
Gene Silencing by RNA
Gene expression (Transcription)
HIV Infection
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (435)
1 – 10 of 435
RGPD2
Tdark
Novelty: 0.02695062
p_int: 0.999999975
p_ni: 5e-9
p_wrong: 2e-8
Score: 0.954
Data Source: BioPlex,STRINGDB
RGPD8
Tdark
Novelty: 0.12397737
p_int: 0.999999952
p_ni: 4.8e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
AKIRIN2
Tbio
Novelty: 0.04603317
p_int: 0.999999711
p_ni: 2.89e-7
Score: 0.77
Data Source: BioPlex,STRINGDB
RANGRF
Tbio
Family: Enzyme
Novelty: 0.02750539
p_int: 0.999998699
p_ni: 2.9e-8
p_wrong: 0.000001272
Score: 0.953
Data Source: BioPlex,STRINGDB
RGPD5
Tbio
Novelty: 0.13776125
p_int: 0.999998547
p_ni: 0.000001453
Score: 0.8
Data Source: BioPlex,STRINGDB
RCC1
Tbio
Novelty: 0.00260884
p_int: 0.999998381
p_ni: 0.000001619
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NEMP2
Tdark
Novelty: 1.47547409
p_int: 0.999993621
p_ni: 1.07e-7
p_wrong: 0.000006271
Score: 0.361
Data Source: BioPlex,STRINGDB
DLGAP5
Tbio
Novelty: 0.01673312
p_int: 0.999922794
p_ni: 0.000050148
p_wrong: 0.000027057
Score: 0.857
Data Source: BioPlex,STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00484823
p_int: 0.999479057
p_ni: 0.000520943
Score: 0.999
Data Source: BioPlex,STRINGDB
CDCA2
Tbio
Novelty: 0.04666018
p_int: 0.999148146
p_ni: 0.000851854
Score: 0.209
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  538.81

PubMed score by year
PubTator Score  1194.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer