You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BCL7A
B-cell CLL/lymphoma 7 protein family member A

Protein Summary
Description
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261822
  • ENSP00000261822
  • ENSG00000110987
  • ENST00000538010
  • ENSP00000445868
  • ENST00000635191
  • ENSP00000489010
  • ENSG00000282873
  • ENST00000635403
  • ENSP00000489305

Symbol
  • BCL7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.72
transcription factor perturbation
0.68
microRNA
0.65
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.3   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
73.9
red blood cell density measurement
1
1
1
73.9
body height
1
1
1
64
body height
1
1
1
64
hemoglobin measurement
1
1
1
41.8
Items per page:
1 – 5 of 11
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
73.9
red blood cell density measurement
1
73.9
body height
1
64
body height
1
64
hemoglobin measurement
1
41.8
Protein-Protein Interactions (91)
1 – 10 of 91
POTEJ
Tdark
Novelty: 3.48973607
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.23
Data Source: BioPlex,STRINGDB
SPIRE1
Tbio
Novelty: 0.04929601
p_int: 0.999999977
p_ni: 1.3e-8
p_wrong: 1e-8
Score: 0.671
Data Source: BioPlex,STRINGDB
PHACTR4
Tbio
Family: Enzyme
Novelty: 0.11366977
p_int: 0.999999971
p_ni: 2.7e-8
p_wrong: 2e-9
Data Source: BioPlex
SPIRE2
Tbio
Novelty: 0.06697946
p_int: 0.999999933
p_ni: 1.2e-8
p_wrong: 5.5e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
PHACTR2
Tbio
Family: Enzyme
Novelty: 0.25056698
p_int: 0.999999889
p_ni: 1.1e-7
Score: 0.439
Data Source: BioPlex,STRINGDB
BRD9
Tchem
Family: Epigenetic
Novelty: 0.03450227
p_int: 0.999999866
p_ni: 1.32e-7
p_wrong: 3e-9
Score: 0.818
Data Source: BioPlex,STRINGDB
MRTFB
Tbio
Novelty: 0.02702072
p_int: 0.999999614
p_ni: 3.52e-7
p_wrong: 3.5e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999999459
p_ni: 5.41e-7
Score: 0.899
Data Source: BioPlex,STRINGDB
BICRA
Tbio
Novelty: 0.13482404
p_int: 0.999999079
p_ni: 9.2e-7
Score: 0.927
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999999079
p_ni: 9.21e-7
Score: 0.907
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.30

PubMed score by year
PubTator Score  8.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: