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Tchem
SLC5A8
Sodium-coupled monocarboxylate transporter 1

Protein Classes
Protein Summary
Description
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000536262
  • ENSP00000445340
  • ENSG00000256870
  • ENST00000572861
  • ENSP00000461697
  • ENSG00000262217

Symbol
  • AIT
  • SMCT
  • SMCT1
  • AIT
  • SMCT
  • SMCT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
cell type or tissue
0.84
cell line
0.58
PubMedID
0.54
biological term
0.53


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.57   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.57   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 8
VGNC:13449
467108
Macaque
solute carrier family 5 member 8
696335
Mouse
MGI:2384916
216225
Rat
RGD:1564146
500820
Dog
solute carrier family 5 member 8
VGNC:46451
482626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 8
Macaque
solute carrier family 5 member 8
Mouse
Rat
Dog
solute carrier family 5 member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N695-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (61)
1 – 10 of 61
SMAP2
Tbio
Novelty: 0.70006863
p_int: 0.996812519
p_ni: 0.000445957
p_wrong: 0.002741524
Data Source: BioPlex
TSPO
Tchem
Novelty: 0.00082324
p_int: 0.991838937
p_ni: 0.004544996
p_wrong: 0.003616068
Score: 0.197
Data Source: BioPlex,STRINGDB
RAB3B
Tbio
Family: Enzyme
Novelty: 0.02731183
p_int: 0.990322313
p_ni: 0.007093363
p_wrong: 0.002584324
Score: 0.159
Data Source: BioPlex,STRINGDB
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.98820131
p_ni: 0.001626498
p_wrong: 0.010172192
Score: 0.182
Data Source: BioPlex,STRINGDB
GK
Tbio
Family: Kinase
Novelty: 0.00617547
p_int: 0.985291546
p_ni: 0.014708453
Data Source: BioPlex
MTX3
Tdark
Novelty: 0.06082176
p_int: 0.975218194
p_ni: 0.024781806
Data Source: BioPlex
TMEM11
Tbio
Novelty: 0.00067837
p_int: 0.97035226
p_ni: 0.022648004
p_wrong: 0.006999736
Data Source: BioPlex
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
p_int: 0.969174122
p_ni: 0.03078842
p_wrong: 0.000037458
Data Source: BioPlex
CORO2A
Tbio
Novelty: 0.03292199
p_int: 0.968876848
p_ni: 0.011389121
p_wrong: 0.019734031
Score: 0.165
Data Source: BioPlex,STRINGDB
SLC25A23
Tbio
Family: Transporter
Novelty: 0.10446757
p_int: 0.960099327
p_ni: 0.039760125
p_wrong: 0.000140548
Data Source: BioPlex
Publication Statistics
PubMed Score  118.57

PubMed score by year
PubTator Score  55.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer