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Tbio
AP1S2
AP-1 complex subunit sigma-2

Protein Summary
Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329235
  • ENSP00000328789
  • ENSG00000182287

Symbol
  • PGS
  • DC22
  • MRX59
  • MRXS5
  • MRXSF
  • MRXS21
  • SIGMA1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
histone modification site profile
0.88
PubMedID
0.77
cellular component
0.76
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
Golgi Associated Vesicle Biogenesis
HIV Infection
Host Interactions of HIV factors
Gene Ontology Terms (13)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (159)
1 – 10 of 159
SYNRG
Tdark
Novelty: 0.03621564
p_int: 1
Score: 0.913
Data Source: BioPlex,STRINGDB
AFTPH
Tbio
Novelty: 0.21887849
p_int: 0.999999999
Score: 0.934
Data Source: BioPlex,STRINGDB
HEATR5B
Tdark
Novelty: 3.21111035
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.561
Data Source: BioPlex,STRINGDB
AP1M2
Tbio
Novelty: 0.02984354
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
AP1G1
Tbio
Novelty: 0.03754132
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AP1G2
Tbio
Novelty: 0.17203425
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
AP1M1
Tbio
Novelty: 0.029282
p_int: 0.999999324
p_ni: 6.76e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AAGAB
Tbio
Novelty: 0.0479209
p_int: 0.999999234
p_ni: 7.66e-7
Score: 0.68
Data Source: BioPlex,STRINGDB
AP1B1
Tbio
Novelty: 0.03370208
p_int: 0.999998972
p_ni: 0.000001028
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999996154
p_ni: 0.000003775
p_wrong: 7.1e-8
Score: 0.894
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  69.61

PubMed score by year
PubTator Score  25.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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