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Tbio
ZNRF3
E3 ubiquitin-protein ligase ZNRF3

Protein Summary
Description
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402174
  • ENSP00000384456
  • ENSG00000183579
  • ENST00000406323
  • ENSP00000384553
  • ENST00000544604
  • ENSP00000443824

Symbol
  • KIAA1133
  • RNF203
  • RNF203
  • BK747E2.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
histone modification site profile
0.74
transcription factor
0.71
tissue sample
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.43   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.43   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
8
2
15
99
waist-hip ratio
5
3
6
98.9
heel bone mineral density
2
4
4
95.7
balding measurement
1
1
1
90
2
2
1
1
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
15
99
waist-hip ratio
6
98.9
heel bone mineral density
4
95.7
balding measurement
1
90
1
1
78.7
Pathways (6)
Regulation of FZD by ubiquitination (R-HSA-4641263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Regulation of FZD by ubiquitination
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Protein-Protein Interactions (43)
1 – 10 of 43
UBE2W
Tbio
Novelty: 0.07255713
p_int: 0.998487338
p_ni: 0.000012133
p_wrong: 0.001500529
Score: 0.22
Data Source: BioPlex,STRINGDB
RSPO2
Tbio
Novelty: 0.0188211
Score: 0.996
Data Source: Reactome,STRINGDB
RSPO1
Tbio
Novelty: 0.00365075
Score: 0.994
Data Source: Reactome,STRINGDB
LGR4
Tbio
Family: GPCR
Novelty: 0.01180123
Score: 0.992
Data Source: Reactome,STRINGDB
LGR5
Tbio
Family: GPCR
Novelty: 0.00105035
Score: 0.987
Data Source: Reactome,STRINGDB
RSPO3
Tbio
Novelty: 0.02321039
Score: 0.984
Data Source: Reactome,STRINGDB
RSPO4
Tbio
Novelty: 0.05670413
Score: 0.982
Data Source: Reactome,STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.97
Data Source: Reactome,STRINGDB
LRP5
Tbio
Novelty: 0.00089807
Score: 0.962
Data Source: STRINGDB
LGR6
Tbio
Family: GPCR
Novelty: 0.02186397
Score: 0.96
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  32.43

PubMed score by year
PubTator Score  21.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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