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Tbio
C2CD5
C2 domain-containing protein 5

Protein Summary
Description
Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333957
  • ENSP00000334229
  • ENSG00000111731
  • ENST00000396028
  • ENSP00000379345
  • ENST00000446597
  • ENSP00000388756
  • ENST00000536386
  • ENSP00000439392
  • ENST00000542676
  • ENSP00000441951
  • ENST00000545552
  • ENSP00000443204

Symbol
  • CDP138
  • KIAA0528
  • CDP138
  • KIAA0528
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor binding site profile
0.94
biological process
0.76
transcription factor perturbation
0.68
cell line
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.8   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
43.8
platelet crit
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
43.8
platelet crit
1
39.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C2 calcium dependent domain containing 5
VGNC:8594
465342
Macaque
C2 calcium dependent domain containing 5
100430610
Mouse
MGI:1921991
74741
Rat
RGD:1304592
362461
Dog
C2 calcium dependent domain containing 5
VGNC:38590
100855606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C2 calcium dependent domain containing 5
Macaque
C2 calcium dependent domain containing 5
Mouse
Rat
Dog
C2 calcium dependent domain containing 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86YS7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Vesicle-mediated transport
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (55)
1 – 10 of 55
FIBP
Tbio
Novelty: 0.11312115
p_int: 0.999999954
p_ni: 3.2e-8
p_wrong: 1.4e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
p_int: 0.999993395
p_ni: 0.000006605
Score: 0.702
Data Source: BioPlex,STRINGDB
DLK1
Tchem
Novelty: 0.00212394
p_int: 0.998714987
p_ni: 0.001285012
Data Source: BioPlex
LZTS2
Tbio
Novelty: 0.09515452
p_int: 0.997450909
p_ni: 0.002549091
Data Source: BioPlex
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
p_int: 0.997309444
p_ni: 0.002689284
p_wrong: 0.000001272
Data Source: BioPlex
NAGK
Tbio
Family: Kinase
Novelty: 0.01603908
p_int: 0.997133095
p_ni: 0.002866891
p_wrong: 1.5e-8
Data Source: BioPlex
WDFY2
Tbio
Novelty: 0.01835759
p_int: 0.995336097
p_ni: 0.004663875
p_wrong: 2.7e-8
Score: 0.243
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.993109913
p_ni: 0.006890059
p_wrong: 2.8e-8
Data Source: BioPlex
AIFM2
Tbio
Novelty: 0.02882373
p_int: 0.976988537
p_ni: 0.023004382
p_wrong: 0.000007081
Data Source: BioPlex
FGF12
Tbio
Novelty: 0.02094849
p_int: 0.971242562
p_ni: 0.028736105
p_wrong: 0.000021333
Data Source: BioPlex
Publication Statistics
PubMed Score  2.80

PubMed score by year
PubTator Score  1.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer