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Tbio
ASIC5
Acid-sensing ion channel 5

Protein Summary
Description
Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000537611
  • ENSP00000442477
  • ENSG00000256394

Symbol
  • ACCN5
  • HINAC
  • INAC
  • ACCN5
  • HINAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
molecular function
0.76
cell line
0.63
tissue sample
0.58
tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.24   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.24   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (11)
1 – 10 of 11
STOML3
Tbio
Novelty: 0.0587281
Score: 0.911
Data Source: Reactome,STRINGDB
STOM
Tbio
Novelty: 0.00459891
Score: 0.905
Data Source: STRINGDB
NCR1
Tbio
Novelty: 0.00282259
Score: 0.591
Data Source: STRINGDB
CTSO
Tbio
Family: Enzyme
Novelty: 0.09963965
Score: 0.581
Data Source: STRINGDB
SLC10A2
Tclin
Family: Transporter
Novelty: 0.0036213
Score: 0.509
Data Source: STRINGDB
AK7
Tbio
Family: Enzyme
Novelty: 0.0283556
Score: 0.472
Data Source: STRINGDB
RBM46
Tbio
Novelty: 0.10180853
Score: 0.471
Data Source: STRINGDB
SHISA5
Tbio
Novelty: 0.18952761
Score: 0.462
Data Source: STRINGDB
SLC5A1
Tclin
Family: Transporter
Novelty: 0.00113611
Score: 0.448
Data Source: STRINGDB
NCR2
Tbio
Novelty: 0.00685029
Score: 0.44
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.24

PubMed score by year
PubTator Score  7.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer